adansononia digitata产品在体外成功调节脂质分布和抑制LDL氧化的有益作用:一项关联研究。

IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Malawi Medical Journal Pub Date : 2022-03-01 DOI:10.4314/mmj.v34i1.5
Ahmed M Ahmed, Omar F Khabour, Amjad Yousuf, Saber M Eweda, Walaa Mohammedsaeed, Haytham M Daradka, Salwa F M Hassanein, Amna M Ibrahim
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引用次数: 0

摘要

背景:近年来,由于药用植物具有许多治疗作用和低副作用,人们对其越来越感兴趣。药用植物中有非洲猴面包树,其果实可食用。在本研究中,研究了牛蒡汁的摄入量对脂质谱的影响。此外,还研究了金钱树精油(EO)对体外低密度脂蛋白胆固醇(LDL-C)氧化的抑制作用。方法:本队列研究共招募a . digitata使用者70例(AD组,男性42例,女性28例)和非a . digitata使用者70例(非AD组,男性44例,女性26例)参与研究。我们评估了所有参与者空腹血液样本中的血脂、HbA1c、肝肾功能和植物甾醇含量。结果:目前的研究结果表明,与非AD组相比,AD组的总胆固醇、甘油三酯和LDL水平显著降低(p < 0.01)。此外,马六甲精油还能显著降低丙二醛(MDA)、蛋白羰基(PC)和脂质过氧化氢(LHP)的生成,从而抑制LDL的体外氧化(P0.05)。结论:天竺葵汁具有降血脂和抗氧化作用,可能有利于控制体内脂质水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The beneficial effect of Adansonia digitata products success to modulate lipid profiles and inhibit LDL oxidation in-vitro: An associational study.

Background: There is a growing interest in medicinal plants in recent years due to their many therapeutic benefits and low side effects. Among the medicinal plants is the African Adansonia digitata (baobab) that has edible fruit. In the current study, the effect of A. digitata juice consumption on the lipid profile was investigated. In addition, inhibition of the oxidation of low-density lipoprotein cholesterol (LDL-C) in-vitro by A. digitata essential oil (EO) was also investigated.

Methods: In this cohort study, a total of 70 subjects of A. digitata users (AD group, 42 male and 28 female) and 70 non A. digitata users (Non-AD group, 44 male and 26 female) were recruited to participate in this study. We evaluated lipid profile, HbA1c, liver/kidney functions, and phytosterol contents in fasting blood samples of all participants.

Results: The present findings illustrated significantly lower levels of total cholesterol, triglycerides, and LDL in the AD group compared to Non-AD (p < 0.01). In addition, essential oil of A. digitata inhibited LDL oxidation in-vitro as shown by the significant decreases in the formation of malonaldehyde (MDA), protein carbonyl (PC), and lipid hydroperoxide (LHP) (P<0.05). No significant changes in fasting blood glucose, HbA1c, HDL, kidney function, and liver function enzymes between the two groups were detected (P>0.05).

Conclusion: The juice of A. digitata has hypolipidemic and antioxidative effects and might be beneficial for the management of lipid levels in the body.

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来源期刊
Malawi Medical Journal
Malawi Medical Journal Medicine-General Medicine
CiteScore
1.50
自引率
0.00%
发文量
27
审稿时长
>12 weeks
期刊介绍: Driven and guided by the priorities articulated in the Malawi National Health Research Agenda, the Malawi Medical Journal publishes original research, short reports, case reports, viewpoints, insightful editorials and commentaries that are of high quality, informative and applicable to the Malawian and sub-Saharan Africa regions. Our particular interest is to publish evidence-based research that impacts and informs national health policies and medical practice in Malawi and the broader region. Topics covered in the journal include, but are not limited to: - Communicable diseases (HIV and AIDS, Malaria, TB, etc.) - Non-communicable diseases (Cardiovascular diseases, cancer, diabetes, etc.) - Sexual and Reproductive Health (Adolescent health, education, pregnancy and abortion, STDs and HIV and AIDS, etc.) - Mental health - Environmental health - Nutrition - Health systems and health policy (Leadership, ethics, and governance) - Community systems strengthening research - Injury, trauma, and surgical disorders
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