电穿孔技术的最新进展:从实验室到临床。

IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI:10.1146/annurev-bioeng-110220-023800
Sabrina N Campelo, Po-Hsun Huang, Cullen R Buie, Rafael V Davalos
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引用次数: 0

摘要

在过去的十年中,越来越多的采用基于电穿孔的技术导致了临床研究计划的扩展。电穿孔在分子生物学中用于哺乳动物和细菌转染;食品卫生;在治疗环境中增加药物摄取,用于基因治疗,消除癌变组织。我们首先讨论理解细胞渗透现象(即电穿孔)背后的概念所需的生物物理学。然后,我们回顾了纳米和微尺度的单细胞电穿孔技术,然后扩大到新兴的体内应用。
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Recent Advancements in Electroporation Technologies: From Bench to Clinic.

Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular biology for mammalian and bacterial transfection; for food sanitation; and in therapeutic settings to increase drug uptake, for gene therapy, and to eliminate cancerous tissues. We begin this article by discussing the biophysics required for understanding the concepts behind the cell permeation phenomenon that is electroporation. We then review nano- and microscale single-cell electroporation technologies before scaling up to emerging in vivo applications.

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来源期刊
Annual Review of Biomedical Engineering
Annual Review of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
18.80
自引率
0.00%
发文量
14
期刊介绍: Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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