电穿孔技术的最新进展:从实验室到临床。

IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI:10.1146/annurev-bioeng-110220-023800
Sabrina N Campelo, Po-Hsun Huang, Cullen R Buie, Rafael V Davalos
{"title":"电穿孔技术的最新进展:从实验室到临床。","authors":"Sabrina N Campelo, Po-Hsun Huang, Cullen R Buie, Rafael V Davalos","doi":"10.1146/annurev-bioeng-110220-023800","DOIUrl":null,"url":null,"abstract":"<p><p>Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular biology for mammalian and bacterial transfection; for food sanitation; and in therapeutic settings to increase drug uptake, for gene therapy, and to eliminate cancerous tissues. We begin this article by discussing the biophysics required for understanding the concepts behind the cell permeation phenomenon that is electroporation. We then review nano- and microscale single-cell electroporation technologies before scaling up to emerging in vivo applications.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":12.8000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Advancements in Electroporation Technologies: From Bench to Clinic.\",\"authors\":\"Sabrina N Campelo, Po-Hsun Huang, Cullen R Buie, Rafael V Davalos\",\"doi\":\"10.1146/annurev-bioeng-110220-023800\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular biology for mammalian and bacterial transfection; for food sanitation; and in therapeutic settings to increase drug uptake, for gene therapy, and to eliminate cancerous tissues. We begin this article by discussing the biophysics required for understanding the concepts behind the cell permeation phenomenon that is electroporation. We then review nano- and microscale single-cell electroporation technologies before scaling up to emerging in vivo applications.</p>\",\"PeriodicalId\":50757,\"journal\":{\"name\":\"Annual Review of Biomedical Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":12.8000,\"publicationDate\":\"2023-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual Review of Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-bioeng-110220-023800\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/2/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1146/annurev-bioeng-110220-023800","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

在过去的十年中,越来越多的采用基于电穿孔的技术导致了临床研究计划的扩展。电穿孔在分子生物学中用于哺乳动物和细菌转染;食品卫生;在治疗环境中增加药物摄取,用于基因治疗,消除癌变组织。我们首先讨论理解细胞渗透现象(即电穿孔)背后的概念所需的生物物理学。然后,我们回顾了纳米和微尺度的单细胞电穿孔技术,然后扩大到新兴的体内应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Recent Advancements in Electroporation Technologies: From Bench to Clinic.

Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular biology for mammalian and bacterial transfection; for food sanitation; and in therapeutic settings to increase drug uptake, for gene therapy, and to eliminate cancerous tissues. We begin this article by discussing the biophysics required for understanding the concepts behind the cell permeation phenomenon that is electroporation. We then review nano- and microscale single-cell electroporation technologies before scaling up to emerging in vivo applications.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Annual Review of Biomedical Engineering
Annual Review of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
18.80
自引率
0.00%
发文量
14
期刊介绍: Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
期刊最新文献
Use of Artificial Intelligence Techniques to Assist Individuals with Physical Disabilities. Critical Advances for Democratizing Ultrasound Diagnostics in Human and Veterinary Medicine. Mechanobiology of Hyaluronan: Connecting Biomechanics and Bioactivity in Musculoskeletal Tissues. Low-Field, Low-Cost, Point-of-Care Magnetic Resonance Imaging. 3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1