类风湿关节炎患者TNF-α对冠心病的影响及TNF-α拮抗剂与冠心病的关系:系统综述

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology Research and Practice Pub Date : 2022-08-24 eCollection Date: 2022-01-01 DOI:10.1155/2022/6192053

Yezhou Qian, Menghui Mao, Feige Nian

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引用次数: 4

摘要

肿瘤坏死因子α（TNF-α）在冠心病（CHD）这一慢性炎症过程中起着重要作用。同时，这种促炎因子也参与了类风湿性关节炎（RA）等自身免疫性疾病的发病机制。RA患者患冠心病的风险较高。TNF-α拮抗剂是治疗RA的主要药物之一，可降低RA患者患冠心病的风险。本文综述了TNF-α在冠心病中的发病机制，并探讨了TNF-a拮抗剂与RA患者冠心病的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Effect of TNF-α on CHD and the Relationship between TNF-α Antagonist and CHD in Rheumatoid Arthritis: A Systematic Review.

Tumor necrosis factor-alpha (TNF-α) plays an important role in coronary heart disease (CHD), a chronic inflammatory process. Meanwhile, this pro-inflammatory factor is also involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Patients with RA correspond to a higher risk of CHD. TNF-α antagonist, one of the main treatments for RA, may reduce the risk of CHD in patients with RA. This review summarizes the pathogenesis of TNF-α in CHD and discusses the relationship between TNF-α antagonist and CHD in patients with RA.

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来源期刊

Cardiology Research and Practice Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.40

自引率

0.00%

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审稿时长

13 weeks

期刊介绍： Cardiology Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies that focus on the diagnosis and treatment of cardiovascular disease. The journal welcomes submissions related to systemic hypertension, arrhythmia, congestive heart failure, valvular heart disease, vascular disease, congenital heart disease, and cardiomyopathy.