埃塞俄比亚东部Jugol总医院2型糖尿病患者他汀类药物的处方模式及相关因素:一项横断面研究。

Shambel Nigussie, Fekade Demeke
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引用次数: 0

摘要

背景:大多数临床实践指南支持在2型糖尿病患者中使用他汀类药物以降低心血管疾病的风险。然而,对埃塞俄比亚东部Jugol总医院的他汀类药物的处方模式一无所知。目的:本研究旨在评估埃塞俄比亚东部Jugol总医院就诊的2型糖尿病患者他汀类药物的处方模式及其相关因素。方法:对2017年6月1日至2022年6月1日接受随访治疗的423例2型糖尿病患者进行回顾性横断面研究。研究参与者采用方便抽样技术连续登记。使用数据抽象检查表从患者的医疗记录中提取数据。提取的数据输入EpiData 3.1版本,导出到SPSS (Statistical Package for The Social Sciences) 22版本进行分析。在p值< 0.05时认为相关性具有统计学意义,并以调整后的优势比和95%置信区间表示。结果:回顾了423例患者的病历。审查显示,其中410名患者的医疗记录是完整的,这些记录被纳入分析。大多数研究参与者为女性(72.2%),年龄在40至65岁之间(61.2%)。所有的研究参与者都有资格服用他汀类药物;然而,只有257名(62.7%)研究参与者开了他汀类药物。在他汀类药物的处方中,40名(15.6%)心血管疾病高危患者服用了中等剂量的他汀类药物。阿托伐他汀是最常见的他汀类药物(93.3%)。高血压、冠状动脉疾病和脑血管事件的存在与他汀类药物处方显著相关。结论:与临床实践指南推荐相比,2型糖尿病患者的他汀类药物处方量较低。这一发现令人震惊,并呼吁采取行动,改善临床实践指南的执行,以造福这一高危人群。
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Prescribing patterns of statins and associated factors among type 2 diabetes mellitus patients attended at Jugol General Hospital in eastern Ethiopia: A cross-sectional study.

Background: Most clinical practice guidelines support the use of statins in patients with type 2 diabetes mellitus to lower the risk of cardiovascular disease. However, nothing is known about the prescribing patterns of statins at Jugol General Hospital in eastern Ethiopia.

Objective: This study aimed to assess the prescribing patterns of statins and associated factors among type 2 diabetes mellitus patients attended at Jugol General Hospital in eastern Ethiopia.

Methods: A retrospective cross-sectional study was conducted among 423 patients with type 2 diabetes mellitus who received follow-up care from 1 June 2017 to 1 June 2022. The study participants were enrolled consecutively using a convenience sampling technique. The data were extracted from patients' medical records using a data abstraction checklist. The extracted data were entered into EpiData, version 3.1, and exported to Statistical Package for the Social Sciences (SPSS), version 22, for analysis. Associations were considered to be statistically significant at a p-value < 0.05 and presented as adjusted odds ratios and 95% confidence intervals.

Result: The medical records of 423 patients were reviewed. The review revealed that medical records were complete for 410 of these patients, and these records were included in the analysis. The majority of the study participants were female (72.2%) and between the age of 40 and 65 years (61.2%). All of the study participants were eligible for statin prescription; however, statins were prescribed for only 257 (62.7%) study participants. Of the statins prescribed, moderate-dose-intensity statins were prescribed for 40 (15.6%) participants who were at high risk of cardiovascular disease. Atorvastatin was the most commonly (93.3%) prescribed statin. The presence of hypertension, coronary artery disease, and cerebrovascular events was significantly associated with statin prescribing.

Conclusion: The magnitude of prescribing statins for patients with type 2 diabetes mellitus was low in comparison with the clinical practice guidelines recommendation. This finding is alarming and is a call for action to improve the execution of clinical practice guidelines for the benefit of this high-risk population.

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