脑血管病与COVID-19:系统综述和荟萃分析

Q2 Medicine Infezioni in Medicina Pub Date : 2023-01-01 DOI:10.53854/liim-3102-2
Ritesh G Menezes, Tamim Omar Alabduladhem, Ahmed Kamal Siddiqi, Muhammad Talha Maniya, Abdulaziz Mazen Al Dahlawi, Mohammed Waleed Abdulaziz Almulhim, Hadeel Waleed Almulhim, Yasmeen Abdulwahab Ali Saeed, Moath Saad Alotaibi, Sarah Saud Alarifi, Abdulrahman Mohammed Alkathiry, Talal Almas
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引用次数: 2

摘要

背景:COVID-19与急性脑血管病(CVD)的关系尚未得到广泛探讨。新数据的出现可能会改变以前的结果。方法:我们查询PubMed电子数据库从建立到2022年2月,评估COVID-19患者卒中发生率的研究。使用随机效应模型汇总分析结果,并以95%置信区间(95% ci)的优势比(ORs)表示。结果:37项研究包括294,249例患者纳入我们的分析。合并结果显示,COVID-19阳性患者急性心血管事件发生率为2.6% (95% CI: 2.0-3.3;结论:COVID-19感染与急性CVD风险增加相关,并与COVID-19阳性患者的心栓子和隐源性病因以及房颤、冠状动脉疾病、糖尿病和高血压等危险因素相关。
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Cerebrovascular disease in COVID-19: a systematic review and meta-analysis.

Background: The association between COVID-19 and acute cerebrovascular disease (CVD) has not been explored extensively. New data has come to light which may change previous results.

Methods: We queried the PubMed electronic database from its inception until February 2022 for studies evaluating the incidence of stroke in COVID-19 patients. Results of the analysis were pooled using a random-effects model and presented as odds ratios (ORs) with 95% confidence intervals (95% CIs).

Results: 37 studies consisting of 294,249 patients were included in our analysis. Pooled results show that the incidence of acute CVD events in COVID-19 positive patients is 2.6% (95% CI: 2.0-3.3; P<0.001). Cardioembolic (OR=14.15, 95% CI: 11.01 to 18.19, P<0.00001) and cryptogenic (OR=2.87, 95% CI: 1.91 to 4.32, P<0.00001) etiologies were associated with COVID-19 positivity. Risk factors for CVD events in patients with COVID-19 were atrial fibrillation (OR=2.60, 95% CI: 1.15 to 5.87, P=0.02), coronary artery disease (OR=2.24, 95% CI: 1.38 to 3.61, P=0.0010), diabetes (OR=2.46, 95% CI: 1.36 to 4.44, P=0.003) and hypertension (OR=3.65, 95% CI: 1.69 to 7.90, P=0.005).

Conclusion: COVID-19 infection is associated with an increased risk for acute CVD and is associated with cardioembolic and cryptogenic etiologies and the risk factors of atrial fibrillation, coronary artery disease, diabetes and hypertension in COVID-19 positive patients.

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来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
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