{"title":"硝基蓝四氮唑试验的使用:在COVID-19背景下重新审视","authors":"Erukkambattu Jayashankar, Ujjawal Khurana, Neelkamal Kapoor","doi":"10.1055/s-0042-1757418","DOIUrl":null,"url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a pandemic caused by β coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-COV2) in which the virus binds to host cells via angiotensin-converting enzyme receptor, and the primary T cell immune response leads to recovery in asymptomatic/ mild infections. 1,2 However, in severe and critical type of illness, SARS-COV2 elicits an aberrant immune response involving interplay of events such as oxidative stress, lym-phocytic cytolysis, release of cytokines, chemotaxis, neutro-philia, and formation of neutrophil extracellular traps (NETs). 3 Increased levels of circulating NETs indicate neutrophil activity. The viral pathogenicity and altered immune response together led to deleterious series of events culmi-nating in acute respiratory distress syndrome (ARDS) and coagulopathy. is de fi","PeriodicalId":16149,"journal":{"name":"Journal of Laboratory Physicians","volume":"15 2","pages":"321-323"},"PeriodicalIF":0.9000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/36/10-1055-s-0042-1757418.PMC10264120.pdf","citationCount":"0","resultStr":"{\"title\":\"Use of Nitroblue Tetrazolium Test: Revisited in Context of COVID-19.\",\"authors\":\"Erukkambattu Jayashankar, Ujjawal Khurana, Neelkamal Kapoor\",\"doi\":\"10.1055/s-0042-1757418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Coronavirus disease 2019 (COVID-19) is a pandemic caused by β coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-COV2) in which the virus binds to host cells via angiotensin-converting enzyme receptor, and the primary T cell immune response leads to recovery in asymptomatic/ mild infections. 1,2 However, in severe and critical type of illness, SARS-COV2 elicits an aberrant immune response involving interplay of events such as oxidative stress, lym-phocytic cytolysis, release of cytokines, chemotaxis, neutro-philia, and formation of neutrophil extracellular traps (NETs). 3 Increased levels of circulating NETs indicate neutrophil activity. The viral pathogenicity and altered immune response together led to deleterious series of events culmi-nating in acute respiratory distress syndrome (ARDS) and coagulopathy. is de fi\",\"PeriodicalId\":16149,\"journal\":{\"name\":\"Journal of Laboratory Physicians\",\"volume\":\"15 2\",\"pages\":\"321-323\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/36/10-1055-s-0042-1757418.PMC10264120.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Laboratory Physicians\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0042-1757418\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Laboratory Physicians","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0042-1757418","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Use of Nitroblue Tetrazolium Test: Revisited in Context of COVID-19.
Coronavirus disease 2019 (COVID-19) is a pandemic caused by β coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-COV2) in which the virus binds to host cells via angiotensin-converting enzyme receptor, and the primary T cell immune response leads to recovery in asymptomatic/ mild infections. 1,2 However, in severe and critical type of illness, SARS-COV2 elicits an aberrant immune response involving interplay of events such as oxidative stress, lym-phocytic cytolysis, release of cytokines, chemotaxis, neutro-philia, and formation of neutrophil extracellular traps (NETs). 3 Increased levels of circulating NETs indicate neutrophil activity. The viral pathogenicity and altered immune response together led to deleterious series of events culmi-nating in acute respiratory distress syndrome (ARDS) and coagulopathy. is de fi