西马鲁肽在70岁以上患者中的疗效和安全性的真实世界研究结果。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-06-20 DOI:10.23736/S2724-6507.23.03985-4
Maria D Garcia DE Lucas, Luis Perez-Belmonte, Beatriz Aviles-Bueno, Anabel Jimenez-Millan, Francisco Rivas Ruiz, José P Miramontes-González
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引用次数: 0

摘要

背景:本研究的目的是调查两家西班牙医院70岁以上的2型糖尿病(T2DM)患者中每周一次的西马鲁肽的使用情况。方法:设计观察性、回顾性、多中心临床研究。该研究包括60例T2DM患者,平均年龄76.5岁,63.3%为女性,T2DM发展平均15.5年,所有患者均在门诊治疗。主要终点是HbA1c从基线到研究结束的变化。次要终点包括体重变化和HbA1c达到5%的患者比例。结果:随访12个月后,HbA1c降低为-0.61±0.9% (P1c水平)。结论:在西班牙的常规临床实践中,每周1次使用西马鲁肽与70岁以上T2DM成人HbA1c和体重改善相关,且具有统计学意义和临床相关性,无显著不良反应,支持实际应用。
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Results of semaglutide in patients older than 70 years, a real-world study of efficacy and safety.

Background: The aim of this study is to investigate the use of once-weekly semaglutide in a real population of patients with type 2 diabetes mellitus (T2DM) over 70 years in two Spanish hospitals.

Methods: An observational, retrospective, and multicenter clinical study was designed. It included 60 patients with T2DM, with a mean age of 76.5 years, 63.3% women, and a mean of 15.5 years of evolution of T2DM, all managed in the outpatient clinical setting. The primary endpoint was the change in HbA1c from baseline to the end of the study. The secondary endpoints included changes in body weight and the proportion of patients achieving HbA1c <7.0% and body weight loss >5%.

Results: After 12 months of follow-up, the reductions in HbA1c were -0.61±0.9% (P<0.0001) in the total cohort. Body weight reductions were -8.2±5.3 kg (P<0.0001). Overall, 67% reached the objective of an HbA1c level of <7%, and 73% achieved a weight loss of ≥5%.

Conclusions: In routine clinical practice in Spain, the use of semaglutide once a week was associated with statistically significant and clinically relevant improvements in HbA1c and body weight in adults aged over 70 years with T2DM, without notable adverse effects, which supports real-world use.

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