SR蛋白家族在植物和动物中已建立的和新兴的作用。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-05-01 DOI:10.1002/wrna.1763
Kundan Kumar, Shubham Kumar Sinha, Upasana Maity, Pulugurtha Bharadwaja Kirti, Koppolu Raja Rajesh Kumar
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引用次数: 5

摘要

前体mrna的剪接是真核生物基因表达的重要组成部分。富丝氨酸/精氨酸(SR)蛋白是存在于所有后生动物和植物中的高度保守的rna结合蛋白。SR蛋白参与构成剪接和选择性剪接,从而调节生物体的转录组和蛋白质组多样性。除了剪接作用外,SR蛋白还参与mRNA输出、无义介导的mRNA衰变、mRNA稳定性和翻译。SR蛋白在mRNA代谢中起关键作用,在正常生长发育中起重要作用。因此,这组蛋白质的任何失调都会导致植物和动物的发育缺陷。来自动物王国的SR蛋白因其规范和非规范功能而被广泛研究。与动物界相比,植物基因组中含有更多的SR蛋白编码基因和更大的SR蛋白多样性,这可能是为植物特异性功能而进化的。来自植物和动物的证据证实了SR蛋白作为影响细胞过程、发育阶段和疾病状况的基因表达调节剂的重要作用。本文分类如下:RNA加工>剪接机制RNA加工>剪接调控/选择性剪接。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Insights into established and emerging roles of SR protein family in plants and animals.

Splicing of pre-mRNA is an essential part of eukaryotic gene expression. Serine-/arginine-rich (SR) proteins are highly conserved RNA-binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and proteome diversity in the organism. In addition to their role in splicing, SR proteins are also involved in mRNA export, nonsense-mediated mRNA decay, mRNA stability, and translation. Due to their pivotal roles in mRNA metabolism, SR proteins play essential roles in normal growth and development. Hence, any misregulation of this set of proteins causes developmental defects in both plants and animals. SR proteins from the animal kingdom are extensively studied for their canonical and noncanonical functions. Compared with the animal kingdom, plant genomes harbor more SR protein-encoding genes and greater diversity of SR proteins, which are probably evolved for plant-specific functions. Evidence from both plants and animals confirms the essential role of SR proteins as regulators of gene expression influencing cellular processes, developmental stages, and disease conditions. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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