生物制剂在慢性鼻窦炎治疗中的作用。

IF 5.4 2区医学 Q1 IMMUNOLOGY BioDrugs Pub Date : 2023-07-01 DOI:10.1007/s40259-023-00602-9

Nora Haloob, Katerina Karamali, Claire Hopkins

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引用次数: 1

摘要

在过去的十年中，生物制剂在治疗慢性鼻窦炎伴鼻息肉(CRSwNP)方面取得了重大进展。基于对下气道2型炎症性疾病病理生理学的了解以及与CRSwNP的强相关性的转化研究已经带来了重大的治疗突破，在撰写本文时，四种生物制剂的3期试验已经完成，更多的生物制剂正在进行中。本文探讨了CRSwNP生物制剂背后的证据，其使用指南以及影响其在这种常见慢性疾病的既定治疗方案中的地位的健康经济因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Biologics in the Treatment of Chronic Rhinosinusitis.

The last decade has seen significant developments in the field of biologics for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). Translational research borne from knowledge of the pathophysiology of type 2 inflammatory disease of the lower airways and the strong association with CRSwNP, has led to major therapeutic breakthroughs, with phase 3 trials of four biologics completed at the time of writing, and more underway. This article explores the evidence behind biologics for CRSwNP, the guidance on their use and the health economic factors influencing their position amongst the established therapeutic options for this common chronic condition.

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来源期刊

BioDrugs 医学-免疫学

CiteScore

12.60

自引率

2.90%

发文量

审稿时长

>12 weeks

期刊介绍： An essential resource for R&D professionals and clinicians with an interest in biologic therapies. BioDrugs covers the development and therapeutic application of biotechnology-based pharmaceuticals and diagnostic products for the treatment of human disease. BioDrugs offers a range of additional enhanced features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by a Key Points summary, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist patients, caregivers and others in understanding important medical advances. The journal also provides the option to include various other types of enhanced features including slide sets, videos and animations. All enhanced features are peer reviewed to the same high standard as the article itself. Peer review is conducted using Editorial Manager®, supported by a database of international experts. This database is shared with other Adis journals.