TNF拮抗剂能成为前列腺增生患者的一种新的治疗策略吗?

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2022-06-07 eCollection Date: 2022-06-01 DOI:10.15698/cst2022.06.268
Renee E Vickman, Omar E Franco, Simon W Hayward
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引用次数: 1

摘要

肿瘤坏死因子(TNF)被广泛认为是全身和局部炎症过程中的关键因素。由于这种分子在驱动慢性和急性炎症方面发挥着关键作用,它是最早用于自身免疫(AI)疾病患者的治疗靶点之一。虽然前列腺的炎症很常见,但该器官以前从未被认为是与某些人工智能疾病相关的全身炎症的靶点。在良性前列腺增生(BPH)患者中,慢性炎症很常见,免疫细胞在器官中占很大比例。炎症细胞的积聚可能是对初始损伤的反应和/或推动BPH发病机制的因素。当然,炎症会限制现有药物治疗对这些患者的疗效。我们之前发现,进展为适应症特异性手术的患者前列腺增生组织中的基因表达模式与AI疾病中的变化一致。最近,我们证明,与没有AI疾病的患者相比,患有AI疾病的病人BPH患病率增加了约50%。AI疾病患者的治疗,特别是使用TNF拮抗剂,可以将BPH的发病率降低到基线人群BPH诊断率以下,或者在某些疾病中,降低到基线群体BPH的诊断率以下。用广谱抗炎甲氨蝶呤治疗AI疾病患者并没有导致诊断的减少。TNF拮抗剂的全身治疗减少了两种前列腺增生小鼠模型和人类患者前列腺组织中的上皮增殖和巨噬细胞积聚。这些研究表明TNF是前列腺增生患者的潜在治疗靶点。
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Could TNF-antagonists be a novel treatment strategy for BPH patients?

Tumor necrosis factor (TNF) is widely recognized as a pivotal player in both systemic and local inflammatory processes. Due to the critical role this molecule has in driving both chronic and acute inflammation, it was among the earliest therapeutic targets utilized for patients with autoimmune (AI) diseases. While inflammation in the prostate is commonly observed, the organ has not previously been considered a target of systemic inflammation associated with some AI diseases. In patients with benign prostatic hyperplasia (BPH), chronic inflammation is common, and immune cells represent a significant proportion of cells in the organ. Accumulation of inflammatory cells may be a response to an initial insult and/or a factor in driving BPH pathogenesis. Certainly, inflammation can limit the efficacy of existing medical therapies in these patients. We previously showed that a pattern of gene expression in BPH tissues from patients who had progressed to indication-specific surgery was consistent with the changes seen in AI diseases. Recently, we demonstrated that patients with AI disease have an approximately 50% increase in BPH prevalence compared to patients without AI disease. Treatment of AI disease patients, specifically with TNF-antagonists, reduces BPH incidence back to, or in some diseases, below, the baseline population BPH diagnosis rate. Treatment of AI disease patients with the broad spectrum anti-inflammatory methotrexate did not elicit this reduction in diagnoses. Systemic treatment with TNF antagonists reduces epithelial proliferation and macrophage accumulation in the prostate tissues from two mouse models of prostatic hyperplasia as well as human patients. These studies suggest that TNF is a potential therapeutic target in BPH patients.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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