肌肉间脂肪组织对肥胖、老化和运动之间代谢变化的重要作用:系统综述》。

TouchREVIEWS in endocrinology Pub Date : 2023-05-01 Epub Date: 2023-05-17 DOI:10.17925/EE.2023.19.1.54
I Gusti Putu Suka Aryana, Ivana Beatrice Paulus, Sanjay Kalra, Dian Daniella, Raden Ayu Tuty Kuswardhani, Ketut Suastika, Sony Wibisono
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引用次数: 0

摘要

随着年龄的增长,脂肪组织会渗入肌肉组织,导致肌肉疏松症。当脂肪组织过度堆积并伴随着瘦体重(尤其是内脏脂肪)的逐渐减少时,就被称为肌肉疏松性肥胖症(SO)和相关的代谢肌间脂肪组织(IMAT),它是一种存在于肌肉群之间的异位组织,有别于皮下脂肪组织。到目前为止,人们还不了解肌间脂肪组织与代谢健康之间的关系。本研究是首次对 IMAT 与代谢健康之间的关系进行评估的系统性综述。我们在 PubMed、Science Direct 和 Cochrane 数据库中搜索了报告 IMAT 和代谢风险的研究。对提取数据的描述以系统性综述首选报告项目(PRISMA)声明为指导,并采用了建议分级评估、开发和评价方法。本研究已在 PROSPERO 注册(标识符:CRD42022337518)。采用纽卡斯尔渥太华量表和循证医学中心检查表对六项研究进行了汇总和审查。其中包括两项临床试验和四项观察性试验。我们的研究结果表明,IMAT 与代谢风险有关,尤其是在老年人和肥胖症患者中。然而,对于腹型肥胖患者来说,VAT 在代谢风险中的作用比 IMAT 更大。将有氧训练与阻力训练相结合可最大程度地降低 IMAT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Important Role of Intermuscular Adipose Tissue on Metabolic Changes Interconnecting Obesity, Ageing and Exercise: A Systematic Review.

As age increases, adipose tissue infiltrates muscle tissue and leads to sarcopenia. When excessive accumulation of adipose tissue accompanied progressive decrease in lean body mass especially visceral fat, termed as sarcopenic obesity (SO) and related metabolic intermuscular adipose tissue (IMAT) is an ectopic tissue found between muscle groups, and is distinct from subcutaneous adipose tissue. Until now, the association between IMAT and metabolic health was not understood. This study is the first systematic review assessing the association between IMAT and metabolic health. The PubMed, Science Direct and Cochrane databases were searched for studies reporting IMAT and metabolic risk. The descriptions of the extracted data are guided by the Preferred Reporting Items for Systematic Reviews (PRISMA) statement with a Grading of Recommendations Assessment, Development and Evaluation approach. This study is registered at PROSPERO (identifier: CRD42022337518). Six studies were pooled and reviewed using critical appraisal by the Newcastle Ottawa Scale and Centre for Evidence-Based Medicine checklist. Two clinical trials and four observational trials were included. Our results reveal that IMAT is associated with metabolic risk, especially in older adults and patients with obesity. However, in a person with abdominal obesity, VAT has a more significant role in metabolic risk than IMAT. The largest decrease in IMAT was achieved by combining aerobic with resistance training.

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