雪貂是病毒性呼吸道疾病的模型。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Comparative medicine Pub Date : 2023-06-01 Epub Date: 2023-05-31 DOI:10.30802/AALAS-CM-22-000064
Rachel E Smith, Shambhunath Choudhary, Julita A Ramirez
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引用次数: 0

摘要

自20世纪初以来,家养雪貂(Mustela putorius furo)已被用于生物医学研究,以研究流感病毒。由于雪貂的疾病易感性和与人类的解剖相似性,它们在病毒性呼吸道疾病的研究中一直具有重要意义。在这里,我们回顾了雪貂生物学和管理的特点,当计划与这个物种一起工作时,应该考虑到这一点,特别是在呼吸道疾病的模型中。我们特别讨论生物安全和饲养,临床和病理评估,以及麻醉考虑与呼吸系统疾病和全身疾病的雪貂。这些考虑对于动物福利、模型对人类疾病的保真度以及确保获得的数据的准确性和可重复性都很重要。最后,我们通过讨论雪貂的呼吸解剖以及2种经常被研究的病毒性呼吸道疾病,流感和冠状病毒病2019 (COVID-19),简要回顾了雪貂在呼吸道疾病研究中的应用。
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Ferrets as Models for Viral Respiratory Disease.

Domestic ferrets (Mustela putorius furo) have been used in biomedical research to study influenza viruses since the early 20th century. Ferrets have continued to gain importance for the study of viral respiratory disease due to their disease susceptibility and anatomic similarities to humans. Here we review features of ferret biology and management that should be considered when planning to work with this species, particularly in models of respiratory disease. We specifically discuss biosafety and husbandry, clinical and pathologic assessments, and anesthetic considerations for ferrets with respiratory disease and systemic illness. These considerations are important for animal welfare, fidelity of the model to human disease, and ensuring accuracy and reproducibility of acquired data. Finally, we briefly review the use of ferrets to study respiratory diseases by discussing their respiratory anatomy and 2 frequently studied viral respiratory diseases, influenza and coronavirus disease 2019 (COVID-19).

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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