具有分层多孔结构的聚醚醚酮种植体促进骨整合。

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-06-27 DOI:10.1186/s40824-023-00407-5
Zhiyong Chen, Yu Chen, Yang Wang, JiaJia Deng, Xin Wang, Qingqing Wang, Yuehua Liu, Jiandong Ding, Lin Yu
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引用次数: 1

摘要

背景:良好的骨融合是骨种植体长期稳定的关键。热塑性聚醚醚酮(PEEK)已广泛应用于骨科;但其固有的生物惰性导致纤维组织包裹其表面,导致骨整合性差,极大地限制了其临床应用。方法:在此,我们开发了一种简单有效的表面改性策略。在致孔剂存在的情况下,常用的磺化与“冷压”处理在PEEK表面形成三维分层多孔结构。随后,研究了多孔表面对大鼠骨髓间充质干细胞(BMSCs)体外粘附、增殖和分化的影响。最后,在大鼠股骨远端缺损模型中研究了表面多孔PEEK植入物的骨诱导和骨整合性。结果:体外实验结果表明,表面改性对PEEK物质的力学性能和细胞相容性没有明显影响,改性PEEK基质上的多孔结构为细胞向内生长提供了空间,增强了骨髓间充质干细胞的成骨分化和矿化。体内实验表明,表面多孔PEEK种植体可有效促进新骨形成,具有较高的骨-种植体接触率,从而与周围宿主骨实现良好的骨融合。此外,该改良技术也成功地在医用PEEK椎间融合器上进行了演示。结论:拓扑形态在种植体骨整合中起着关键作用,我们开发的这种简便有效的修复策略有望很快实现实际应用。
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Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration.

Background: Good osseointegration is the key to the long-term stability of bone implants. Thermoplastic polyetheretherketone (PEEK) has been widely used in orthopedics; however, its inherent biological inertia causes fibrous tissue to wrap its surface, which leads to poor osseointegration and thus greatly limits its clinical applications.

Methods: Herein, we developed a facile yet effective surface modification strategy. A commonly used sulfonation coupled with "cold pressing" treatment in the presence of porogenic agent formed a three-dimensional hierarchical porous structure on PEEK surface. Subsequently, the effects of porous surface on the in vitro adhesion, proliferation and differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) were evaluated. Finally, the osteoinduction and osseointegration of surface-porous PEEK implant were examined in the rat distal femoral defect model.

Results: In vitro results showed that the surface modification did not significantly affect the mechanical performance and cytocompatibility of PEEK substance, and the porous structure on the modified PEEK substrate provided space for cellular ingrowth and enhanced osteogenic differentiation and mineralization of BMSCs. In vivo tests demonstrated that the surface-porous PEEK implant could effectively promote new bone formation and had higher bone-implant contact rate, thereby achieving good bone integration with the surrounding host bone. In addition, this modification technique was also successfully demonstrated on a medical PEEK interbody fusion cage.

Conclusion: The present study indicates that topological morphology plays a pivotal role in determining implant osseointegration and this facile and effective modification strategy developed by us is expected to achieve practical applications quickly.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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