乌干达接受多路地韦为基础的抗逆转录病毒治疗的成人高血压患病率及相关因素:一项横断面研究

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE Integrated Blood Pressure Control Pub Date : 2023-01-01 DOI:10.2147/IBPC.S403023
Ronald Kasoma Mutebi, Andrew Weil Semulimi, John Mukisa, Martha Namusobya, Joy Christine Namirembe, Esther Alice Nalugga, Charles Batte, David Mukunya, Bruce Kirenga, Robert Kalyesubula, Pauline Byakika-Kibwika
{"title":"乌干达接受多路地韦为基础的抗逆转录病毒治疗的成人高血压患病率及相关因素:一项横断面研究","authors":"Ronald Kasoma Mutebi,&nbsp;Andrew Weil Semulimi,&nbsp;John Mukisa,&nbsp;Martha Namusobya,&nbsp;Joy Christine Namirembe,&nbsp;Esther Alice Nalugga,&nbsp;Charles Batte,&nbsp;David Mukunya,&nbsp;Bruce Kirenga,&nbsp;Robert Kalyesubula,&nbsp;Pauline Byakika-Kibwika","doi":"10.2147/IBPC.S403023","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Dolutegravir-based anti-retroviral therapy (ART) regimens were rolled out as first line HIV treatment in Uganda due to their tolerability, efficacy and high resistance barrier to human immunodeficiency virus (HIV). They have however been associated with weight gain, dyslipidemia and hyperglycemia which are cardiometabolic risk factors of hypertension. We assessed the prevalence and factors associated with hypertension among adults on dolutegravir regimens.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on 430 systematically sampled adults on dolutegravir-based ART for ≥ 6 months. Hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or history of use of antihypertensive agents.</p><p><strong>Results: </strong>The prevalence of hypertension was 27.2% (117 of 430 participants) [95% CI: 23.2-31.6]. Majority were female (70.7%), the median age 42 [34, 50] years, with body mass index (BMI) ≥ 25 kg/m<sup>3</sup> (59.6%) and median duration on DTG-based regimens of 28 [15, 33] months. Being male [aPR: 1.496, 95% CI: 1.122-1.994, P = 0.006], age ≥ 45 years [aPR: 4.23, 95% CI: 2.206-8.108, P < 0.001] and 35-44 years [aPR: 2.455, 95% CI: 1.216-4.947, P < 0.012] as compared with age < 35 years, BMI ≥ 25 kg/m<sup>3</sup> [aPR: 1.489, 95% CI: 1.072-2.067, P = 0.017] as compared with BMI < 25 kg/m<sup>3</sup>, duration on dolutegravir-based ART [aPR: 1.008, 95% CI: 1.001-1.015, P = 0.037], family history of hypertension [aPR: 1.457, 95% CI: 1.064-1.995, P = 0.019] and history of heart disease [aPR: 1.73, 95% CI: 1.205-2.484, P = 0.003] were associated with hypertension.</p><p><strong>Conclusion: </strong>One in every four people with HIV (PWH) on dolutegravir-based ART has hypertension. We recommend the integration of hypertension management in the HIV treatment package and policies to improve existing supply chains for low cost and high-quality hypertension medications.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":"16 ","pages":"11-21"},"PeriodicalIF":1.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/f2/ibpc-16-11.PMC10123006.pdf","citationCount":"2","resultStr":"{\"title\":\"Prevalence of and Factors Associated with Hypertension Among Adults on Dolutegravir-Based Antiretroviral Therapy in Uganda: A Cross Sectional Study.\",\"authors\":\"Ronald Kasoma Mutebi,&nbsp;Andrew Weil Semulimi,&nbsp;John Mukisa,&nbsp;Martha Namusobya,&nbsp;Joy Christine Namirembe,&nbsp;Esther Alice Nalugga,&nbsp;Charles Batte,&nbsp;David Mukunya,&nbsp;Bruce Kirenga,&nbsp;Robert Kalyesubula,&nbsp;Pauline Byakika-Kibwika\",\"doi\":\"10.2147/IBPC.S403023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Dolutegravir-based anti-retroviral therapy (ART) regimens were rolled out as first line HIV treatment in Uganda due to their tolerability, efficacy and high resistance barrier to human immunodeficiency virus (HIV). They have however been associated with weight gain, dyslipidemia and hyperglycemia which are cardiometabolic risk factors of hypertension. We assessed the prevalence and factors associated with hypertension among adults on dolutegravir regimens.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on 430 systematically sampled adults on dolutegravir-based ART for ≥ 6 months. Hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or history of use of antihypertensive agents.</p><p><strong>Results: </strong>The prevalence of hypertension was 27.2% (117 of 430 participants) [95% CI: 23.2-31.6]. Majority were female (70.7%), the median age 42 [34, 50] years, with body mass index (BMI) ≥ 25 kg/m<sup>3</sup> (59.6%) and median duration on DTG-based regimens of 28 [15, 33] months. Being male [aPR: 1.496, 95% CI: 1.122-1.994, P = 0.006], age ≥ 45 years [aPR: 4.23, 95% CI: 2.206-8.108, P < 0.001] and 35-44 years [aPR: 2.455, 95% CI: 1.216-4.947, P < 0.012] as compared with age < 35 years, BMI ≥ 25 kg/m<sup>3</sup> [aPR: 1.489, 95% CI: 1.072-2.067, P = 0.017] as compared with BMI < 25 kg/m<sup>3</sup>, duration on dolutegravir-based ART [aPR: 1.008, 95% CI: 1.001-1.015, P = 0.037], family history of hypertension [aPR: 1.457, 95% CI: 1.064-1.995, P = 0.019] and history of heart disease [aPR: 1.73, 95% CI: 1.205-2.484, P = 0.003] were associated with hypertension.</p><p><strong>Conclusion: </strong>One in every four people with HIV (PWH) on dolutegravir-based ART has hypertension. We recommend the integration of hypertension management in the HIV treatment package and policies to improve existing supply chains for low cost and high-quality hypertension medications.</p>\",\"PeriodicalId\":45299,\"journal\":{\"name\":\"Integrated Blood Pressure Control\",\"volume\":\"16 \",\"pages\":\"11-21\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/f2/ibpc-16-11.PMC10123006.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Integrated Blood Pressure Control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/IBPC.S403023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrated Blood Pressure Control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/IBPC.S403023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 2

摘要

导语:基于dolutegravvir的抗逆转录病毒疗法(ART)方案由于其耐受性、有效性和对人类免疫缺陷病毒(HIV)的高抗性屏障,在乌干达作为一线艾滋病毒治疗方案推出。然而,它们与体重增加、血脂异常和高血糖有关,这些都是高血压的心脏代谢危险因素。我们评估了使用多替格拉韦治疗的成年人中高血压的患病率和相关因素。方法:我们对430名系统抽样的成年人进行了横断面研究,这些成年人接受了以盐酸孕酮为基础的抗逆转录病毒治疗≥6个月。高血压被定义为收缩压≥140 mmHg或舒张压≥90 mmHg或使用抗高血压药物的历史。结果:高血压患病率为27.2% (117 / 430)[95% CI: 23.2-31.6]。大多数为女性(70.7%),中位年龄42[34,50]岁,体重指数(BMI)≥25 kg/m3(59.6%),以dtg为基础的方案中位持续时间为28[15,33]个月。被男性[4月:1.496,95%置信区间CI: 1.122 - -1.994, P = 0.006),≥45岁(4月:4.23,95%置信区间CI: 2.206 - -8.108, P < 0.001]和35-44年[4月:2.455,95%置信区间CI: 1.216 - -4.947, P < 0.012),与年龄< 35年,BMI≥25公斤/立方米(4月:1.489,95%置信区间CI: 1.072 - -2.067, P = 0.017)与体重指数< 25公斤/立方米,持续时间dolutegravir-based艺术[4月:1.008,95%置信区间CI: 1.001 - -1.015, P = 0.037),高血压家族史(4月:1.457,95%置信区间CI: 1.064 - -1.995, P = 0.019)和心脏病史的[4月:[1.73, 95% CI: 1.205 ~ 2.484, P = 0.003]与高血压相关。结论:每4名接受以盐酸孕酮为基础的抗逆转录病毒治疗的HIV感染者中就有1人患有高血压。我们建议将高血压管理纳入艾滋病毒治疗方案和政策,以改善低成本和高质量高血压药物的现有供应链。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Prevalence of and Factors Associated with Hypertension Among Adults on Dolutegravir-Based Antiretroviral Therapy in Uganda: A Cross Sectional Study.

Introduction: Dolutegravir-based anti-retroviral therapy (ART) regimens were rolled out as first line HIV treatment in Uganda due to their tolerability, efficacy and high resistance barrier to human immunodeficiency virus (HIV). They have however been associated with weight gain, dyslipidemia and hyperglycemia which are cardiometabolic risk factors of hypertension. We assessed the prevalence and factors associated with hypertension among adults on dolutegravir regimens.

Methods: We conducted a cross-sectional study on 430 systematically sampled adults on dolutegravir-based ART for ≥ 6 months. Hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or history of use of antihypertensive agents.

Results: The prevalence of hypertension was 27.2% (117 of 430 participants) [95% CI: 23.2-31.6]. Majority were female (70.7%), the median age 42 [34, 50] years, with body mass index (BMI) ≥ 25 kg/m3 (59.6%) and median duration on DTG-based regimens of 28 [15, 33] months. Being male [aPR: 1.496, 95% CI: 1.122-1.994, P = 0.006], age ≥ 45 years [aPR: 4.23, 95% CI: 2.206-8.108, P < 0.001] and 35-44 years [aPR: 2.455, 95% CI: 1.216-4.947, P < 0.012] as compared with age < 35 years, BMI ≥ 25 kg/m3 [aPR: 1.489, 95% CI: 1.072-2.067, P = 0.017] as compared with BMI < 25 kg/m3, duration on dolutegravir-based ART [aPR: 1.008, 95% CI: 1.001-1.015, P = 0.037], family history of hypertension [aPR: 1.457, 95% CI: 1.064-1.995, P = 0.019] and history of heart disease [aPR: 1.73, 95% CI: 1.205-2.484, P = 0.003] were associated with hypertension.

Conclusion: One in every four people with HIV (PWH) on dolutegravir-based ART has hypertension. We recommend the integration of hypertension management in the HIV treatment package and policies to improve existing supply chains for low cost and high-quality hypertension medications.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Integrated Blood Pressure Control
Integrated Blood Pressure Control PERIPHERAL VASCULAR DISEASE-
CiteScore
4.60
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊最新文献
Prevalence and Predictors of Depression Symptoms Among Afghan Hypertensive Patients: Secondary Analysis of a Multi-Center Cross-Sectional Study. Prevalence of Risk Factors for Hypertension Among Faculty at an Urban University in Uganda [Response to Letter]. Resistance Training in Cardiovascular Diseases: A Review on Its Effectiveness in Controlling Risk Factors. Thoughts on "Prevalence of Risk Factors for Hypertension Among Faculty at an Urban University in Uganda" [Letter]. Adherence to Lifestyle Modification Practices and Its Associated Factors Among Hypertensive Patients in Bahir Dar City Hospitals, North West Ethiopia [Letter].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1