华南汉族人群CYP4F2基因变异与缺血性卒中易感性相关

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2023-01-01 DOI:10.2147/PGPM.S413632

Kang Huang, Tianyi Ma, Qiang Li, Yilei Zhou, Ting Qin, Zanrui Zhong, Shilin Tang, Wei Zhang, Jianghua Zhong, Shijuan Lu

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引用次数: 0

摘要

背景:缺血性脑卒中的病理生理机制复杂。传统的危险因素不能完全或部分解释IS的发生和发展。遗传因素越来越受到人们的重视。我们的研究旨在探讨CYP4F2基因多态性与IS易感性之间的关系。方法:通过SNPStats在线软件对1322名志愿者进行关联分析。使用FPRP(假阳性报告概率)来检测结果是否值得注意。通过多因素降维评估SNP-SNP在IS风险中的相互作用。本研究的统计分析主要通过SPSS 22.0软件完成。结果:CYP4F2-rs2108622突变等位基因A (OR = 1.24)和基因型AA (OR = 1.49)、GA (OR = 1.26)是IS的危险遗传因素。Rs2108622在年龄>60岁、BMI≥24 kg/m2、吸烟或饮酒的女性受试者中与is风险增加显著相关。CYP4F2-rs3093106和-rs3093105与吸烟、饮酒或IS合并高血压患者的IS易感性相关。结论:CYP4F2-rs2108622、-rs3093106和-rs3093105与IS风险增加相关。

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Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China.

Background: The pathophysiological mechanism of ischemic stroke is complex. Traditional risk factors cannot fully or only partially explain the occurrence and development of IS. Genetic factors are getting more and more attention. Our study aimed to explore the association between CYP4F2 gene polymorphism and susceptibility to IS.

Methods: A total of 1322 volunteers were enrolled to perform an association analysis through SNPStats online software. Using FPRP (false-positive report probability) to detect whether the result is a noteworthy finding. The interaction of SNP-SNP in IS risk was assessed by multi-factor dimensionality reduction. Statistical analysis of this study was mainly completed by SPSS 22.0 software.

Results: Mutant allele "A" (OR = 1.24) and genotype "AA" (OR = 1.49) or "GA" (OR = 1.26) of CYP4F2-rs2108622 are risk genetic factors for IS. Rs2108622 is significantly associated with an increased risk of IS among subjects who are females, aging >60 years old, with BMI ≥24 kg/m², and smoking or drinking volunteers. CYP4F2-rs3093106 and -rs3093105 are associated with susceptibility to IS among smoking, drinking subjects, or IS patients complicated with hypertension.

Conclusion: CYP4F2-rs2108622, -rs3093106, and -rs3093105 are associated with an increased risk of IS.

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来源期刊

Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

3.30

自引率

5.30%

发文量

110

审稿时长

16 weeks

期刊介绍： Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.