ALK3在骨关节炎中的多重作用。

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING Bone & Joint Research Pub Date : 2023-07-03 DOI:10.1302/2046-3758.127.BJR-2022-0310.R1
Xianchun Ruan, Jinning Gu, Mingyang Chen, Fulin Zhao, Munire Aili, Demao Zhang
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引用次数: 1

摘要

骨关节炎(OA)是一种慢性退行性关节疾病,以进行性软骨退化、滑膜炎症、骨赘形成和软骨下骨硬化为特征。软骨和软骨下骨的病理改变是骨性关节炎的主要过程。近几十年来,许多研究表明,激活素样激酶3 (ALK3)是一种骨形态发生蛋白受体,对软骨形成、成骨和出生后骨骼发育至关重要。尽管骨形态发生蛋白(bone morphogenetic protein, BMP)信号在关节软骨和骨中的作用已被广泛研究,但近年来围绕关节软骨、软骨下骨中的ALK3靶点以及两者之间的相互作用有了许多新发现,拓宽了对ALK3与OA关系的原有认识。本文就ALK3在骨性关节炎(包括软骨和软骨下骨及相关细胞)中的作用进行综述。这可能有助于在未来寻找更有效的基于ALK3信号的OA药物或治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Multiple roles of ALK3 in osteoarthritis.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis. Pathological changes in cartilage and subchondral bone are the main processes in OA. In recent decades, many studies have demonstrated that activin-like kinase 3 (ALK3), a bone morphogenetic protein receptor, is essential for cartilage formation, osteogenesis, and postnatal skeletal development. Although the role of bone morphogenetic protein (BMP) signalling in articular cartilage and bone has been extensively studied, many new discoveries have been made in recent years around ALK3 targets in articular cartilage, subchondral bone, and the interaction between the two, broadening the original knowledge of the relationship between ALK3 and OA. In this review, we focus on the roles of ALK3 in OA, including cartilage and subchondral bone and related cells. It may be helpful to seek more efficient drugs or treatments for OA based on ALK3 signalling in future.

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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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