{"title":"疫苗佐剂概述","authors":"Zhenchuan Wu , Keqin Liu","doi":"10.1016/j.medidd.2021.100103","DOIUrl":null,"url":null,"abstract":"<div><p>Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity. There are many different types of adjuvants with different modes of action. A better understanding of their potential adjuvanticity could provide guidance for the development of novel adjuvants for cancer immunotherapy. In this article, we review the importance of adjuvants in vaccine development, their mechanisms of action and adjuvant-induced autoimmunity and discuss some strategies for driving the development of new vaccine adjuvants.</p></div>","PeriodicalId":33528,"journal":{"name":"Medicine in Drug Discovery","volume":"11 ","pages":"Article 100103"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.medidd.2021.100103","citationCount":"18","resultStr":"{\"title\":\"Overview of vaccine adjuvants\",\"authors\":\"Zhenchuan Wu , Keqin Liu\",\"doi\":\"10.1016/j.medidd.2021.100103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity. There are many different types of adjuvants with different modes of action. A better understanding of their potential adjuvanticity could provide guidance for the development of novel adjuvants for cancer immunotherapy. In this article, we review the importance of adjuvants in vaccine development, their mechanisms of action and adjuvant-induced autoimmunity and discuss some strategies for driving the development of new vaccine adjuvants.</p></div>\",\"PeriodicalId\":33528,\"journal\":{\"name\":\"Medicine in Drug Discovery\",\"volume\":\"11 \",\"pages\":\"Article 100103\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.medidd.2021.100103\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine in Drug Discovery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590098621000245\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine in Drug Discovery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590098621000245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity. There are many different types of adjuvants with different modes of action. A better understanding of their potential adjuvanticity could provide guidance for the development of novel adjuvants for cancer immunotherapy. In this article, we review the importance of adjuvants in vaccine development, their mechanisms of action and adjuvant-induced autoimmunity and discuss some strategies for driving the development of new vaccine adjuvants.
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