极度分化的T细胞亚群有助于衰老过程中的组织退化。

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2023-04-26 DOI:10.1146/annurev-immunol-101721-064501
Gonzalo Soto-Heredero, Manuel M Gómez de Las Heras, J Ignacio Escrig-Larena, María Mittelbrunn
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引用次数: 4

摘要

在衰老过程中,T细胞区室发生了戏剧性的重塑。最臭名昭著的变化是原始T细胞池的减少和记忆样T细胞的积累。老年人的记忆样T细胞获得终末分化细胞的表型,失去共刺激分子的表达,获得衰老细胞的特性。在这篇综述中,我们重点关注在衰老过程中积累的与年龄相关的T细胞的不同亚群。这些亚群包括具有自然杀伤特性的极具细胞毒性的T细胞,细胞因子产生改变的耗竭T细胞,以及具有促炎特征的调节性T细胞。重要的是,所有这些亚群都失去了淋巴结归巢能力,并优先迁移到非淋巴组织,在那里它们导致组织恶化和炎症。
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Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.

There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.

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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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