急性胆囊炎中血小板指数之间的关系：病例对照研究

Revista de gastroenterologia de Mexico (English) Pub Date : 2024-04-01 DOI:10.1016/j.rgmxen.2023.04.012

S. Özdemir , İ. Altunok , A. Özkan , M.M. İslam , A. Algın , S.E. Eroğlu , G. Aksel

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引用次数: 0

摘要

材料与方法在一家三级甲等教学医院开展了一项回顾性病例对照研究。急性胆囊炎组的人口统计学、合并症、实验室数据、住院时间和死亡率数据均从医院数字数据库中回顾性获得。研究还收集了血小板计数、血小板平均体积、血小板crit、血小板分布宽度和血小板质量指数。根据所研究的血小板指数的多变量分析结果，只有平均血小板体积和血小板分布宽度在两组之间有显著差异（调整后的几率比：2，95% 置信区间：1.4-2.7，p <0.001；调整后的几率比：5.88，95% 置信区间：2.44-14.4，p <0.001）。建立的多变量回归模型在预测急性胆囊炎方面的曲线下面积为 0.969（准确性：0.917，敏感性：89%，特异性：94.5%）。

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Relationship between platelet indices in acute cholecystitis: A case-control study

Introduction and aims

We aimed to investigate changes in initial platelet indices in patients arriving at the emergency department with acute cholecystitis.

Material and methods

A retrospective case-control study was conducted at a tertiary care teaching hospital. Demographics, comorbidities, laboratory data, length of hospital stay, and mortality data for the acute cholecystitis group were retrospectively obtained from the hospital digital database. Platelet count, mean platelet volume, plateletcrit, platelet distribution width, and platelet mass index were collected.

Results

A total of 553 patients with acute cholecystitis were the study cases, and 541 hospital employees were the study controls. According to the results of the multivariate analysis of the platelet indices studied, only mean platelet volume and platelet distribution width showed significant differences between the two groups (adjusted odds ratio: 2, 95% confidence interval: 1.4−2.7, p < 0.001 and adjusted odds ratio: 5.88, 95% confidence interval: 2.44−14.4, p < 0.001, respectively). The multivariate regression model created had an area under the curve of 0.969 in the prediction of acute cholecystitis (accuracy: 0.917, sensitivity: 89%, and specificity: 94.5%).