PIWIL1单核苷酸多态性对中国人群胃癌风险的影响

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Genetic testing and molecular biomarkers Pub Date : 2023-06-01 DOI:10.1089/gtmb.2022.0061
Dan Hu, Laicheng Wang, Xin Chen, Yunchai Lin, Shunpeng Zhang, Zongcheng Fan, Feng Peng
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To investigate the efficacy of PIWIL1 SNPs genotype on the morbidity and mortality of GC and its interaction within PIWIL1 gene SNPs variation and between elevated plasma glucose. <b><i>Materials and Methods:</i></b> We conducted a case-control study that contained 216 GC patients and 204 cancer-free controls to compare differential expression of PIWIL1 SNPs. <b><i>Results:</i></b> PIWIL1 gene rs1106042 AA and AG genotypes were associated with significantly reduced GC risk (odds ratio [OR]: 0.15 and 0.26, <i>p</i> < 0.001 and <i>p</i> = 0.016), and rs10773771 CT+CC type significantly increased cancer risk (OR: 1.54 <i>p</i> = 0.037). We observed strong associations between rs10773771 and pathological type (<i>p</i> = 0.012), rs11703684, and invasion depth (<i>p</i> = 0.012). We noticed significant gene-gene interaction between rs1106042 and rs10773771 (<i>p</i> = 0.0107). Interaction between the copresence of rs1106042 GG plus hyperglycemia was also significant (relative excess risk due to interaction: 28.78, attributable proportion due to interaction: 68.2%, synergy index: 3.32). Patients with rs1892723 TT and rs1892722 GG+GA type had better survival (<i>p</i> = 0.030 and <i>p</i> = 0.048). <b><i>Conclusion:</i></b> rs10773771 CT+CC was associated with GC risk increase, rs1106042 AA and AG function as a protective factor. rs1892723 CT+TT and rs1892722 AA type may portend a poor prognosis. 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引用次数: 0

摘要

背景:piwi样蛋白参与癌变的发生和进展。PIWI-like 1 (PIWIL1)基因的单核苷酸多态性(snp)是否影响胃癌(GC)的发病率和死亡率尚不清楚。目的探讨PIWIL1 snp基因型对胃癌发病率和死亡率的影响及其与PIWIL1基因内snp变异和血糖升高之间的相互作用。材料和方法:我们进行了一项病例对照研究,包括216例胃癌患者和204例无癌对照,比较PIWIL1 snp的差异表达。结果:PIWIL1基因rs1106042 AA和AG基因型与胃癌风险显著降低相关(比值比[OR]: 0.15和0.26,p p = 0.016), rs10773771 CT+CC基因型与胃癌风险显著升高相关(OR: 1.54 p = 0.037)。我们观察到rs10773771与病理类型(p = 0.012)、rs11703684与侵袭深度(p = 0.012)有很强的相关性。我们发现rs1106042和rs10773771之间存在显著的基因-基因互作(p = 0.0107)。rs1106042 GG的存在与高血糖之间的相互作用也很显著(相互作用的相对超额风险:28.78,相互作用的归因比例:68.2%,协同指数:3.32)。rs1892723 TT和rs1892722 GG+GA型患者生存率更高(p = 0.030和p = 0.048)。结论:rs10773771 CT+CC与胃癌风险增加相关,rs1106042 AA和AG为保护因素。rs1892723 CT+TT和rs1892722 AA型可能预示预后不良。空腹血糖升高会通过增殖相互作用显著增加PIWIL基因rs1106042 GG致癌的风险。
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Impact of PIWIL1 Single Nucleotide Polymorphisms on Gastric Cancer Risk in a Chinese Population.

Background: PIWI-like proteins contribute to the onset and progression of carcinogenesis. Whether single nucleotide polymorphisms (SNPs) in the PIWI-like 1 (PIWIL1) gene affect the morbidity and mortality of gastric cancer (GC) remains unclear. To investigate the efficacy of PIWIL1 SNPs genotype on the morbidity and mortality of GC and its interaction within PIWIL1 gene SNPs variation and between elevated plasma glucose. Materials and Methods: We conducted a case-control study that contained 216 GC patients and 204 cancer-free controls to compare differential expression of PIWIL1 SNPs. Results: PIWIL1 gene rs1106042 AA and AG genotypes were associated with significantly reduced GC risk (odds ratio [OR]: 0.15 and 0.26, p < 0.001 and p = 0.016), and rs10773771 CT+CC type significantly increased cancer risk (OR: 1.54 p = 0.037). We observed strong associations between rs10773771 and pathological type (p = 0.012), rs11703684, and invasion depth (p = 0.012). We noticed significant gene-gene interaction between rs1106042 and rs10773771 (p = 0.0107). Interaction between the copresence of rs1106042 GG plus hyperglycemia was also significant (relative excess risk due to interaction: 28.78, attributable proportion due to interaction: 68.2%, synergy index: 3.32). Patients with rs1892723 TT and rs1892722 GG+GA type had better survival (p = 0.030 and p = 0.048). Conclusion: rs10773771 CT+CC was associated with GC risk increase, rs1106042 AA and AG function as a protective factor. rs1892723 CT+TT and rs1892722 AA type may portend a poor prognosis. Elevated fasting plasma glucose will significantly increase the risk of PIWIL gene rs1106042 GG carcinogenesis by multiplicative interaction.

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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
63
审稿时长
1 months
期刊介绍: Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling
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