{"title":"在临床实践中测量性类固醇的建议。SEQCML/SEEN/SEEP的位置声明。","authors":"Gregori Casals, Roser Ferrer Costa, Eulàlia Urgell Rull, Héctor F Escobar-Morreale, Jesús Argente, Gemma Sesmilo, Betina Biagetti","doi":"10.1515/almed-2023-0020","DOIUrl":null,"url":null,"abstract":"<p><p>The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.</p>","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"4 1","pages":"52-69"},"PeriodicalIF":1.1000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197192/pdf/","citationCount":"3","resultStr":"{\"title\":\"Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQC<sup>ML</sup>/SEEN/SEEP.\",\"authors\":\"Gregori Casals, Roser Ferrer Costa, Eulàlia Urgell Rull, Héctor F Escobar-Morreale, Jesús Argente, Gemma Sesmilo, Betina Biagetti\",\"doi\":\"10.1515/almed-2023-0020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.</p>\",\"PeriodicalId\":72097,\"journal\":{\"name\":\"Advances in laboratory medicine\",\"volume\":\"4 1\",\"pages\":\"52-69\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197192/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in laboratory medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/almed-2023-0020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in laboratory medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/almed-2023-0020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQCML/SEEN/SEEP.
The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.
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