下肺型肉瘤病患者的不良预后和死亡率。

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM Canadian respiratory journal Pub Date : 2023-04-15 eCollection Date: 2023-01-01 DOI:10.1155/2023/3624344
Kazunobu Tachibana, Masanori Akira, Toru Arai, Chikatoshi Sugimoto, Seiji Hayashi, Yoshikazu Inoue
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引用次数: 0

摘要

背景:肺肉瘤病主要影响上肺区,但有时也会影响下肺区。我们假设下肺区为主的肉样瘤患者的基线用力肺活量较低,限制性肺功能进行性下降,长期死亡率较高:我们回顾性地审查了我们的数据库中 2004 年至 2014 年连续 108 例经肺和/或纵隔淋巴结活检病理证实的肺肉样瘤病患者的临床数据,包括肺功能检测:11例(10.2%)肺下区为主的肉样瘤病患者与97例非肺下区为主的肉样瘤病患者进行了比较。下肺区占位患者的中位年龄明显较大(71岁对56岁,P = 0.0005)。低位优势患者的基线强迫生命容量(FVC)百分比明显较低(96.0% 对 103%,p = 0.022)。低位优势患者的 FVC 年变化为 -112 mL,而非低位优势患者为 0 mL(p = 0.0033)。在低位优势组中,有三名患者(27%)出现致命的急性病情恶化。下占位组的总生存率明显较低:结论:肺下区显性肉样瘤病患者年龄较大,基线 FVC 较低,疾病进展和急性恶化与较高的长期死亡率相关。
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Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis.

Background: Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality.

Methods: We retrospectively reviewed clinical data including the pulmonary function tests of 108 consecutive patients with pulmonary sarcoidosis pathologically confirmed by lung and/or mediastinal lymph node biopsy from 2004 to 2014 from our database.

Results: Eleven patients (10.2%) with lower lung zone-dominant sarcoidosis were compared with 97 patients with nonlower lung zone-dominant sarcoidosis. The median age of the patients with lower dominance was significantly older (71 vs. 56, p = 0.0005). The patient with lower dominance had a significantly lower baseline percent forced vital capacity (FVC) (96.0% vs. 103%, p = 0.022). The annual change in FVC was -112 mL in those with lower dominance vs. 0 mL in nonlower dominance (p = 0.0033). Fatal acute deterioration was observed in three patients (27%) in the lower dominant group. Overall survival in the lower dominant group was significantly worse.

Conclusions: Patients with lower lung zone-dominant sarcoidosis had an older age and lower baseline FVC with disease progression and acute deterioration associated with higher long-term mortality.

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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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