Xiaohu Ouyang, Junfen Zhou, Lan Lin, Zili Zhang, Shanshan Luo, Desheng Hu
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引用次数: 6
摘要
gasdermins (GSDM)是一个成孔蛋白家族，在人类中由gasdermin a (GSDMA)、gasdermin B (GSDMB)、gasdermin C (GSDMC)、gasdermin D (GSDMD)、gasdermin E (GSDME)和DFNB59 (Pejvakin (PJVK))组成。这些蛋白在焦亡中起重要作用。其中，GSDMD是研究最广泛的蛋白，被认为是焦亡的刽子手。其他家庭成员也与某些癌症有关。作为一种独特的程序性细胞死亡形式，焦亡与肿瘤进展和炎性小体密切相关，炎性小体是一种诱导炎症和焦亡的先天免疫机制。本文就焦亡、炎性小体的研究进展作一综述，重点综述气皮蛋白家族成员及其在诱导焦亡中的作用和可能的抗肿瘤治疗价值。
Pyroptosis, inflammasome, and gasdermins in tumor immunity.
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans. These proteins play an important role in pyroptosis. Among them, GSDMD is the most extensively studied protein and is identified as the executioner of pyroptosis. Other family members have also been implicated in certain cancers. As a unique form of programmed cell death, pyroptosis is closely related to tumor progression, and the inflammasome, an innate immune mechanism that induces inflammation and pyroptosis. In this review, we explore the current developments of pyroptosis, the inflammasome, and especially we review the gasdermin family members and their role in inducing pyroptosis and the possible therapeutic values in antitumor effects.
期刊介绍：
Innate Immunity is a highly ranked, peer-reviewed scholarly journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS). The journal welcomes manuscripts from researchers actively working on all aspects of innate immunity including biologically active bacterial, viral, fungal, parasitic, and plant components, as well as relevant cells, their receptors, signaling pathways, and induced mediators. The aim of the Journal is to provide a single, interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants to researchers. The Journal creates a vehicle for the publication of articles encompassing all areas of research, basic, applied, and clinical. The subject areas of interest include, but are not limited to, research in biochemistry, biophysics, cell biology, chemistry, clinical medicine, immunology, infectious disease, microbiology, molecular biology, and pharmacology.
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