{"title":"黑籽(Nigella sativa)治疗COVID-19长期或急性后后遗症(PASC)和持续COVID-19症状的潜力","authors":"Naina Mohamed Pakkir Maideen, Abdurazak Hassan Jumale, Ibrahim Ramadan Barakat, Ayesha Khalifa Albasti","doi":"10.2174/1871526523666230223112045","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care.</p><p><strong>Objective: </strong>This review article focuses on the beneficial effects of black seeds (Nigella sativa) in the management of long COVID and persistent COVID symptoms.</p><p><strong>Methods: </strong>The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of long COVID.</p><p><strong>Results: </strong>Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic properties in various clinical, animal, in vitro, in vivo, and in silico studies, which would help the patients recovered from COVID to mitigate Long COVID complications.</p><p><strong>Conclusion: </strong>Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy in combination with symptomatic treatment and supportive care to prevent further deterioration and hospitalization. The safety and efficacy of N. sativa in patients with Long-COVID would further be established by future randomized controlled clinical trials.</p>","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Potential of Black Seeds (<i>Nigella sativa</i>) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms - An Insight.\",\"authors\":\"Naina Mohamed Pakkir Maideen, Abdurazak Hassan Jumale, Ibrahim Ramadan Barakat, Ayesha Khalifa Albasti\",\"doi\":\"10.2174/1871526523666230223112045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care.</p><p><strong>Objective: </strong>This review article focuses on the beneficial effects of black seeds (Nigella sativa) in the management of long COVID and persistent COVID symptoms.</p><p><strong>Methods: </strong>The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of long COVID.</p><p><strong>Results: </strong>Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic properties in various clinical, animal, in vitro, in vivo, and in silico studies, which would help the patients recovered from COVID to mitigate Long COVID complications.</p><p><strong>Conclusion: </strong>Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy in combination with symptomatic treatment and supportive care to prevent further deterioration and hospitalization. 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引用次数: 1
摘要
背景:一些个体在COVID-19康复后可能会出现持续数月的症状，长期COVID-19患者主要通过对症治疗和支持性护理进行管理。目的:综述黑籽(Nigella sativa)在治疗长时间COVID和持续性COVID症状中的有益作用。方法:在LitCOVID、Web of Science、Google Scholar、bioRxiv、medRxiv、Science Direct、EBSCO、Scopus、Embase等数据库和参考文献列表中检索文献，评价黑籽(N. sativa)对长冠状病毒体征和症状的各种影响。结果:黑籽(N. sativa)在各种临床、动物、体外、体内和计算机研究中显示出潜在的抗COVID、抗病毒、抗炎、抗氧化、免疫调节、降压、抗肥胖、降糖、降血脂和平喘气的特性，有助于患者从COVID中恢复，减轻长期COVID并发症。结论:长冠患者可将黑籽(N. sativa)作为辅助治疗，结合对症治疗和支持护理，防止病情进一步恶化和住院治疗。sativa在Long-COVID患者中的安全性和有效性将通过未来的随机对照临床试验进一步确定。
Potential of Black Seeds (Nigella sativa) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms - An Insight.
Background: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care.
Objective: This review article focuses on the beneficial effects of black seeds (Nigella sativa) in the management of long COVID and persistent COVID symptoms.
Methods: The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of long COVID.
Results: Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic properties in various clinical, animal, in vitro, in vivo, and in silico studies, which would help the patients recovered from COVID to mitigate Long COVID complications.
Conclusion: Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy in combination with symptomatic treatment and supportive care to prevent further deterioration and hospitalization. The safety and efficacy of N. sativa in patients with Long-COVID would further be established by future randomized controlled clinical trials.
期刊介绍：
Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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