健康与疾病中横纹肌细胞内与器官间线粒体通讯。

IF 22 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Endocrine reviews Pub Date : 2023-07-11 DOI:10.1210/endrev/bnad004
Neoma T Boardman, Giulia Trani, Marco Scalabrin, Vanina Romanello, Rob C I Wüst
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引用次数: 7

摘要

线粒体除了传递有关细胞能量状态的信号外,还能感知生化和能量输入。这些信号细胞器越来越被认为是调节不同细胞功能的关键。本文综述了横纹肌中线粒体通讯的最新进展,特别关注线粒体相互之间、其他细胞器之间以及跨远端器官系统的通讯过程。横纹肌中的间歇性线粒体通讯是通过线粒体膜电位传导到邻近线粒体、物理相互作用、线粒体融合或裂变以及通过纳米隧道介导的,从而允许蛋白质、线粒体DNA、核苷酸和肽的交换。在横纹肌细胞内,线粒体与细胞器的通讯可以调节细胞的整体功能。线粒体向身体其他部分传递线粒体适应性的各种机制表明,细胞外线粒体信号是健康和疾病的关键。虽然线粒体来源的囊泡可能会分泌线粒体来源的内分泌化合物,但线粒体应激刺激可导致成纤维细胞生长因子21 (FGF21)和生长分化因子15 (GDF15)释放到循环中,从而调节全身生理。众所周知,循环线粒体DNA是触发免疫系统的警报器,可能有助于解释各种慢性疾病的低度炎症。线粒体功能和通讯受损是常见的心脏和骨骼肌病变的核心,包括心肌病、胰岛素抵抗和肌肉减少症。最后,讨论了线粒体内分泌学、通讯、医学视野和转化方面的重要新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease.

Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the energetic state of the cell. Increasingly, these signaling organelles are recognized as key for regulating different cell functions. This review summarizes recent advances in mitochondrial communication in striated muscle, with specific focus on the processes by which mitochondria communicate with each other, other organelles, and across distant organ systems. Intermitochondrial communication in striated muscle is mediated via conduction of the mitochondrial membrane potential to adjacent mitochondria, physical interactions, mitochondrial fusion or fission, and via nanotunnels, allowing for the exchange of proteins, mitochondrial DNA, nucleotides, and peptides. Within striated muscle cells, mitochondria-organelle communication can modulate overall cell function. The various mechanisms by which mitochondria communicate mitochondrial fitness to the rest of the body suggest that extracellular mitochondrial signaling is key during health and disease. Whereas mitochondria-derived vesicles might excrete mitochondria-derived endocrine compounds, stimulation of mitochondrial stress can lead to the release of fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) into the circulation to modulate whole-body physiology. Circulating mitochondrial DNA are well-known alarmins that trigger the immune system and may help to explain low-grade inflammation in various chronic diseases. Impaired mitochondrial function and communication are central in common heart and skeletal muscle pathologies, including cardiomyopathies, insulin resistance, and sarcopenia. Lastly, important new advances in research in mitochondrial endocrinology, communication, medical horizons, and translational aspects are discussed.

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来源期刊
Endocrine reviews
Endocrine reviews 医学-内分泌学与代谢
CiteScore
42.00
自引率
1.00%
发文量
29
期刊介绍: Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
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