青少年和成人地中海贫血患者体力活动、疼痛和骨骼健康之间的关系:一项观察性研究。

IF 0.6 Q4 HEMATOLOGY Thalassemia Reports Pub Date : 2022-09-01 DOI:10.3390/thalassrep12030014
Ellen B Fung, Elijah K Goldberg, Sakina Bambot, Raquel Manzo, Ashutosh Lal
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引用次数: 0

摘要

地中海贫血(Thal)患者的体力活动少于非Thal人群,这可能导致疼痛和骨质疏松症。本研究的目的是评估当代Thal患者的身体活动、疼痛和低骨量之间的关系。71名Thal患者(50名成人≥18岁,61%男性,82%依赖输血)完成了简短疼痛量表,并验证了青少年和成人的身体活动问卷。近一半的患者报告每天都有躯体疼痛。在控制年龄和性别后,采用多元回归分析,久坐行为与疼痛严重程度呈正相关(p = 0.017, r 2 = 0.28)。只有37%的成年参与者达到了疾病控制与预防中心建议的运动量。符合活动指南的患者脊柱BMD Z-score(-2.1±0.7)高于未符合活动指南的患者(-2.8±1.2,p = 0.048)。在控制输血状态和久坐活动时间后,观察到Thal成人自我报告的身体活动(小时/周)与髋关节BMD Z-score呈正相关(p = 0.009, r2 = 0.25)。这些结果表明,体力活动的减少和久坐行为的增加会导致骨量低,这可能与一些Thal患者的疼痛严重程度有关。研究集中在增加身体活动可能有助于改善骨健康和减轻骨关节炎患者的疼痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Relationships among Physical Activity, Pain, and Bone Health in Youth and Adults with Thalassemia: An Observational Study.

Patients with thalassemia (Thal) engage in less physical activity than non-Thal populations, which may contribute to pain and osteoporosis. The purpose of this study was to assess relationships between physical activity, pain, and low bone mass in a contemporary sample of patients with Thal. Seventy-one patients with Thal (50 adults ≥18 years, 61% male, 82% transfusion-dependent) completed the Brief Pain Inventory Short Form and validated physical activity questionnaires for youth and adults. Nearly half of the patients reported daily somatic pain. Using multiple regression, after controlling for age and gender, sedentary behavior was positively associated with pain severity (p = 0.017, r 2 = 0.28). Only 37% of adult participants met CDC recommendations for physical activity. Spine BMD Z-score was higher (-2.1 ± 0.7) in those who met activity guidelines compared to those who did not (-2.8 ± 1.2, p = 0.048). A positive relationship was observed between self-reported physical activity (hours/week) and hip BMD Z-score in adults with Thal after controlling for transfusion status and sedentary activity time (p = 0.009, r 2 = 0.25). These results suggest that decreased physical activity and increased sedentary behavior contribute to low bone mass, which may be related to pain severity in some patients with Thal. Studies focused on increasing physical activity may contribute to improved bone health and reduced pain in patients with Thal.

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来源期刊
Thalassemia Reports
Thalassemia Reports HEMATOLOGY-
自引率
0.00%
发文量
17
审稿时长
10 weeks
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