Jakub Vanek, Kamila Belohradova Minarikova, Jan Prasko, Samuel Genzor, Dana Subova, Frantisek Hodny, Pavol Pobeha, Jonas Bocek, Marie Ociskova
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引用次数: 0
摘要
目的:惊恐障碍(PD)和阻塞性睡眠呼吸暂停(OSA)都是常见的合并症。本文综述了PD和OSA合并症的知识现状以及对该合并症患者的治疗效果。方法:选取通过PubMed和Web of Science检索得到的文章;出版日期在1990年1月到2022年12月之间。应用的搜索词是:阻塞性睡眠呼吸暂停;恐慌症;CPAP;抗抑郁药;抗焦虑药;抗精神病药物。通过关键词进行主搜索，选择了81篇文章。在对全文进行全面评估后，选出了60篇论文。调查主要文献参考文献中的次要文献，评估其适用性，并将其纳入文献列表(n = 18)。因此，78篇论文被纳入综述文章。结果:研究描述了OSA患者中惊恐障碍的更大患病率。到目前为止，还没有关于PD患者中OSA患病率的数据。关于CPAP治疗对PD的影响的证据有限，这些证据表明CPAP可以部分缓解PD症状。一些研究发现，PD治疗中使用的药物可以显著影响共病性OSA。结论:两种情况之间的关系似乎是双向的，有必要评估OSA患者是否合并惊恐障碍，反之亦然。这两种疾病都可能使对方恶化，必须采用复杂的方法进行治疗，以确保患者的身体健康和心理健康得到改善。
Objective: Both panic disorder (PD) and obstructive sleep apnea (OSA) are frequent conditions that can be comorbid. This article reviews the current state of knowledge about the comorbidity of PD and OSA and the effectiveness of therapy in patients with this comorbidity.
Method: Articles obtained via PubMed and Web of Science search were selected; the publishing date was between January 1990 and December 2022. The applied search terms were: obstructive sleep apnea; panic disorder; CPAP; antidepressants; anxiolytics; antipsychotics. Eighty-one articles were chosen by primary search via keywords. After a complete assessment of the full texts, 60 papers were chosen. Secondary papers from the references of the primary documents were investigated, evaluated for suitability, and included in the list of documents (n = 18). Thus, seventy-eight papers were incorporated into the review article.
Results: Studies describe a greater prevalence of panic disorder in OSA patients. So far, there is no data on the prevalence of OSA in PD patients. Limited evidence is found regarding the influence of CPAP treatment on PD, and this evidence suggests that CPAP can partially alleviate PD symptoms. Medication used in PD treatment can significantly impact comorbid OSA, as explored in several studies.
Conclusions: The relationship between the two conditions seems bidirectional, and it is necessary to assess OSA patients for comorbid panic disorder and vice versa. Both disorders can worsen the other and must be treated with a complex approach to ensure improvement in patients' physical health and psychological well-being.
期刊介绍：
Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology
Letters.
Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered.
The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.
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