Che Muhammad Khairul Hisyam Bin Ismail , Edre Bin Mohammad Aidid , Hairul Aini Binti Hamzah , Mohd Shaiful Ehsan Bin Shalihin , Azmi Bin Md Nor
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CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of <span><em>Streptococcus gallolyticus</em></span> infection with CRC that needs further attention.</p><p>Thus, a case–control study was conducted to determine whether <em>S. gallolyticus</em> infection is a predictor for CRC occurrence among patients attending Sultan Ahmad Shah Medical Centre@IIUM (SASMEC@IIUM).</p></div><div><h3>Patients and methods</h3><p>A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMEC@IIUM were collected and analyzed with iFOBT test and PCR assay to detect <em>S. gallolyticus</em>.</p></div><div><h3>Results</h3><p>In this study, the proportion of <em>S. gallolyticus</em><span> infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis<span> shows that occult blood in stool, </span></span><em>S. gallolyticus</em> infection and family history were significantly associated with the development of CRC (<em>P</em><span> < 0.05). Using the multivariate logistic regression model, positive stool PCR for </span><em>S. gallolyticus</em> had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).</p></div><div><h3>Conclusion</h3><p>This finding suggests that <em>S. gallolyticus</em><span> infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker<span> for early detection of disease progression.</span></span></p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Streptococcus gallolyticus infection: A neglected marker for colorectal cancer?\",\"authors\":\"Che Muhammad Khairul Hisyam Bin Ismail , Edre Bin Mohammad Aidid , Hairul Aini Binti Hamzah , Mohd Shaiful Ehsan Bin Shalihin , Azmi Bin Md Nor\",\"doi\":\"10.1016/j.ajg.2023.02.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and study aims</h3><p>Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of <span><em>Streptococcus gallolyticus</em></span> infection with CRC that needs further attention.</p><p>Thus, a case–control study was conducted to determine whether <em>S. gallolyticus</em> infection is a predictor for CRC occurrence among patients attending Sultan Ahmad Shah Medical Centre@IIUM (SASMEC@IIUM).</p></div><div><h3>Patients and methods</h3><p>A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMEC@IIUM were collected and analyzed with iFOBT test and PCR assay to detect <em>S. gallolyticus</em>.</p></div><div><h3>Results</h3><p>In this study, the proportion of <em>S. gallolyticus</em><span> infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis<span> shows that occult blood in stool, </span></span><em>S. gallolyticus</em> infection and family history were significantly associated with the development of CRC (<em>P</em><span> < 0.05). Using the multivariate logistic regression model, positive stool PCR for </span><em>S. gallolyticus</em> had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).</p></div><div><h3>Conclusion</h3><p>This finding suggests that <em>S. gallolyticus</em><span> infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker<span> for early detection of disease progression.</span></span></p></div>\",\"PeriodicalId\":48674,\"journal\":{\"name\":\"Arab Journal of Gastroenterology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arab Journal of Gastroenterology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1687197923000114\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1687197923000114","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景和研究目的:癌症是马来西亚第二常见的癌症,由于缺乏对结直肠癌症状和体征的认识,大多在晚期发现。CRC的发病机制是多因素的,有不明确的证据表明溶没食子链球菌感染与CRC有关,需要进一步关注。因此,进行了一项病例对照研究,以确定溶没食子酸链球菌感染是否是Sultan Ahmad Shah Medical就诊患者CRC发生的预测因素Centre@IIUM(SASMEC@IIUM).患者和方法:共有33份来自诊断为CRC的患者的粪便样本和80份来自参加SASMEC@IIUM收集并用iFOBT试验和PCR分析来检测溶没食子酸链球菌。结果:在本研究中,CRC患者中溶没食子酸链球菌感染的比例(48.5%)高于对照组(20%)。单因素分析表明,粪便潜血、溶没食子酸链球菌感染和家族史与CRC的发展显著相关(P结论:这一发现表明,在我们的研究中,溶没食子酸杆菌感染是CRC发展的最强预测因素,并可能成为早期检测疾病进展的预测标志。
Streptococcus gallolyticus infection: A neglected marker for colorectal cancer?
Background and study aims
Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention.
Thus, a case–control study was conducted to determine whether S. gallolyticus infection is a predictor for CRC occurrence among patients attending Sultan Ahmad Shah Medical Centre@IIUM (SASMEC@IIUM).
Patients and methods
A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMEC@IIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus.
Results
In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%).
Conclusion
This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression.
期刊介绍:
Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.