Amel Youssef Shehab, Amal Farahat Allam, Awad Abd El Kader Saad, Mervat Mostafa Osman, Heba Said Ibrahim, Esraa Abdelhamid Moneer, Mona Mohamed Tolba
{"title":"曼氏血吸虫病患者的拟议发病率标志物。","authors":"Amel Youssef Shehab, Amal Farahat Allam, Awad Abd El Kader Saad, Mervat Mostafa Osman, Heba Said Ibrahim, Esraa Abdelhamid Moneer, Mona Mohamed Tolba","doi":"10.4103/tp.tp_46_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.</p><p><strong>Aim and objectives: </strong>The present work aimed to evaluate FC and FOB as morbidity markers of <i>Schistosoma mansoni</i> infection before and after praziquantel treatment.</p><p><strong>Materials and methods: </strong>A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.</p><p><strong>Results: </strong><i>S. mansoni</i> prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured <i>S. mansoni</i> cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high <i>S. mansoni</i> infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.</p><p><strong>Conclusion: </strong>FC and FOB could be possibly used as morbidity monitoring tools for <i>S. mansoni</i> infection in children with moderate and high infection intensity.</p>","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"13 1","pages":"40-45"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321587/pdf/","citationCount":"0","resultStr":"{\"title\":\"Proposed morbidity markers among <i>Schistosoma mansoni</i> patients.\",\"authors\":\"Amel Youssef Shehab, Amal Farahat Allam, Awad Abd El Kader Saad, Mervat Mostafa Osman, Heba Said Ibrahim, Esraa Abdelhamid Moneer, Mona Mohamed Tolba\",\"doi\":\"10.4103/tp.tp_46_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.</p><p><strong>Aim and objectives: </strong>The present work aimed to evaluate FC and FOB as morbidity markers of <i>Schistosoma mansoni</i> infection before and after praziquantel treatment.</p><p><strong>Materials and methods: </strong>A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.</p><p><strong>Results: </strong><i>S. mansoni</i> prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured <i>S. mansoni</i> cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high <i>S. mansoni</i> infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.</p><p><strong>Conclusion: </strong>FC and FOB could be possibly used as morbidity monitoring tools for <i>S. mansoni</i> infection in children with moderate and high infection intensity.</p>\",\"PeriodicalId\":37825,\"journal\":{\"name\":\"Tropical Parasitology\",\"volume\":\"13 1\",\"pages\":\"40-45\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321587/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tropical Parasitology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/tp.tp_46_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/5/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical Parasitology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/tp.tp_46_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Proposed morbidity markers among Schistosoma mansoni patients.
Background: Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.
Aim and objectives: The present work aimed to evaluate FC and FOB as morbidity markers of Schistosoma mansoni infection before and after praziquantel treatment.
Materials and methods: A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.
Results: S. mansoni prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured S. mansoni cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high S. mansoni infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.
Conclusion: FC and FOB could be possibly used as morbidity monitoring tools for S. mansoni infection in children with moderate and high infection intensity.
期刊介绍：
Tropical Parasitology, a publication of Indian Academy of Tropical Parasitology, is a peer-reviewed online journal with Semiannual print on demand compilation of issues published. The journal’s full text is available online at www.tropicalparasitology.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of parasitology. Articles with clinical interest and implications will be given preference.
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