基于ipsc的个性化医疗的工程考虑。

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-07-07 DOI:10.1186/s40824-023-00382-x
Sangbae Park, Yonghyun Gwon, Shahidul Ahmed Khan, Kyoung-Je Jang, Jangho Kim
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引用次数: 1

摘要

个性化医疗旨在根据患者的临床、遗传和环境特征提供量身定制的医疗。诱导多能干细胞在个性化医疗领域引起了相当大的关注;然而,多能干细胞的固有局限性阻碍了其在临床应用中的广泛应用。也就是说,开发显著的工程策略来克服目前iPSCs的局限性是很重要的。这种工程方法可以为从iPSC制备到临床应用的现有挑战提供创新的解决方案,从而导致基于iPSC的个性化治疗取得重大进展。在这篇综述中,我们通过将开发过程分为三个不同的步骤,总结了如何使用工程策略来推进基于ipsc的个性化医疗:1)治疗性ipsc的生产;2)治疗性iPSCs的工程化;3)工程诱导多能干细胞的临床应用。具体来说,我们关注的是工程策略及其对基于ipsc的个性化医疗发展的每一步的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Engineering considerations of iPSC-based personalized medicine.

Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environmental characteristics of patients. iPSCs have attracted considerable attention in the field of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread use in clinical applications. That is, it would be important to develop notable engineering strategies to overcome the current limitations of iPSCs. Such engineering approaches could lead to significant advances in iPSC-based personalized therapy by offering innovative solutions to existing challenges, from iPSC preparation to clinical applications. In this review, we summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps: 1) the production of therapeutic iPSCs; 2) engineering of therapeutic iPSCs; and 3) clinical applications of engineered iPSCs. Specifically, we focus on engineering strategies and their implications for each step in the development of iPSC-based personalized medicine.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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