血清CXCL5作为多发性硬化症和视神经脊髓炎谱系障碍的生物标志物。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI:10.14744/nci.2022.77861
Zerrin Karaaslan, Vuslat Yilmaz, Hande Yuceer, Elif Sanli, Halil Ibrahim Akcay, Murat Kurtuncu, Recai Turkoglu, Erdem Tuzun
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引用次数: 0

摘要

目的:我们的目的是确定血清C-X-C基序趋化因子5 (CXCL5)是否可以作为复发-缓解型多发性硬化症(RRMS)的诊断生物标志物以及可用于预测治疗反应的标志物。方法:采用ELISA法检测20例经fingolimod治疗的RRMS患者、10例视神经脊髓炎(NMOSD)患者、15例以脊髓和视神经发作为主的RRMS患者和14例健康对照者血清中CXCL5水平。结果:芬戈莫德治疗显著降低CXCL5水平。NMOSD和MS-SCON患者的CXCL5水平具有可比性。结论:芬戈莫德对先天免疫系统有一定的调节作用。血清CXCL5测定不能区分RRMS和NMOSD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Serum CXCL5 as a biomarker in multiple sclerosis and neuromyelitis optica spectrum disorder.

Objective: Our aim was to determine whether serum C-X-C motif chemokine 5 (CXCL5) may serve as a diagnostic biomarker for relapsing-remitting multiple sclerosis (RRMS) as well as a marker that can be used to predict treatment response.

Methods: CXCL5 levels were measured by ELISA in sera of 20 RRMS patients under fingolimod treatment, 10 neuromyelitis optica spectrum disorder (NMOSD) patients, 15 RRMS patients presenting predominantly with spinal cord and optic nerve attacks (MS-SCON), and 14 healthy controls.

Results: Fingolimod treatment significantly reduced CXCL5 levels. CXCL5 levels were comparable among NMOSD and MS-SCON patients.

Conclusion: Fingolimod might regulate the innate immune system. Serum CXCL5 measurement does not differentiate between RRMS and NMOSD.

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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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