真菌菌群介导的免疫反应:胰腺肿瘤发生和化疗耐药的不可忽视的启动子。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2023-01-01 DOI:10.20517/cdr.2023.06
Yaling Jiang, Valentina Donati, Godefridus J Peters, Elisa Giovannetti, Dong Mei Deng
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引用次数: 0

摘要

胰腺导管腺癌(Pancreatic ductal adenocarcinoma, PDAC)是人类最致命的癌症之一,因其诊断较晚且对治疗反应较差。PDAC的肿瘤微环境(tumor microenvironment, TME)具有独特的抑制免疫特征,抑制抗肿瘤免疫的保护功能,从而促进PDAC的进展。最近,Alam等人的研究首次发现肿瘤内真菌菌群可通过增强一种趋化剂白细胞介素(IL-) 33的分泌,参与PDAC TME中2型免疫细胞的募集和激活。在本文中,我们回顾了本研究的重要发现。结合我们的研究结果,我们综合讨论了真菌菌群在协调免疫反应从而调节肿瘤进展中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fungal mycobiome-mediated immune response: a non-negligible promoter in pancreatic oncogenesis and chemoresistance.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments. The tumor microenvironment (TME) of PDAC is characterized by a distinctive, suppressive immune profile, which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression. Recently, the study of Alam et al. discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant, interleukin (IL-) 33. In this article, we reviewed the important findings of this study. Together with our findings, we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.

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