恩格列净对吲哚美辛诱导的胃粘膜的影响。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-06-01 DOI:10.23736/S2724-6507.21.03425-4
Isilay Taskaldiran, Serife M Kuskonmaz, Pinar Celepli, Sema Hucumenoglu, Cemil Nural, Özcan Erel, Cavit Culha
{"title":"恩格列净对吲哚美辛诱导的胃粘膜的影响。","authors":"Isilay Taskaldiran,&nbsp;Serife M Kuskonmaz,&nbsp;Pinar Celepli,&nbsp;Sema Hucumenoglu,&nbsp;Cemil Nural,&nbsp;Özcan Erel,&nbsp;Cavit Culha","doi":"10.23736/S2724-6507.21.03425-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) are considered a new class antidiabetic agent, as well as lowering blood sugar, it has many positive effects. This study aimed to investigate the effects of SLGT2i on the gastric mucosa.</p><p><strong>Methods: </strong>We investigated the effects of empagliflozin on indomethacin-induced gastritis using 48 male Wistar Albino rats. We performed histopathological evaluations of gastric mucosa tissue. And we studied the levels of serum disulfide, native thiol, total thiol, and ischemia modified albumin, disulfide/native thiol ratio (SSSH), native thiol/total thiol percent ratio (SH total SH), and disulfide/total thiol percent ratio (SS total SH).</p><p><strong>Results: </strong>We found that empagliflozin increased mucin production in rat gastric mucosa. Besides, we observed milder inflammation findings and lower gastritis scores in the empagliflozin receiving groups than the placebo groups. Native thiol, total thiol, and disulfide levels were lower in the indomethacin-induced gastritis groups.</p><p><strong>Conclusions: </strong>This study is the first to investigate the effect of empagliflozin on the gastrointestinal tract in a rat model. We concluded that empagliflozin increased mucin production and revealed positive effects in an indomethacin-induced gastritis model.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"186-193"},"PeriodicalIF":2.5000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Effects of empagliflozin against indomethacin induced gastric mucosa.\",\"authors\":\"Isilay Taskaldiran,&nbsp;Serife M Kuskonmaz,&nbsp;Pinar Celepli,&nbsp;Sema Hucumenoglu,&nbsp;Cemil Nural,&nbsp;Özcan Erel,&nbsp;Cavit Culha\",\"doi\":\"10.23736/S2724-6507.21.03425-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) are considered a new class antidiabetic agent, as well as lowering blood sugar, it has many positive effects. This study aimed to investigate the effects of SLGT2i on the gastric mucosa.</p><p><strong>Methods: </strong>We investigated the effects of empagliflozin on indomethacin-induced gastritis using 48 male Wistar Albino rats. We performed histopathological evaluations of gastric mucosa tissue. And we studied the levels of serum disulfide, native thiol, total thiol, and ischemia modified albumin, disulfide/native thiol ratio (SSSH), native thiol/total thiol percent ratio (SH total SH), and disulfide/total thiol percent ratio (SS total SH).</p><p><strong>Results: </strong>We found that empagliflozin increased mucin production in rat gastric mucosa. Besides, we observed milder inflammation findings and lower gastritis scores in the empagliflozin receiving groups than the placebo groups. Native thiol, total thiol, and disulfide levels were lower in the indomethacin-induced gastritis groups.</p><p><strong>Conclusions: </strong>This study is the first to investigate the effect of empagliflozin on the gastrointestinal tract in a rat model. We concluded that empagliflozin increased mucin production and revealed positive effects in an indomethacin-induced gastritis model.</p>\",\"PeriodicalId\":18690,\"journal\":{\"name\":\"Minerva endocrinology\",\"volume\":\"48 2\",\"pages\":\"186-193\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Minerva endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23736/S2724-6507.21.03425-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S2724-6507.21.03425-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 2

摘要

背景:钠-葡萄糖共转运蛋白2 (SGLT2)抑制剂(SGLT2i)被认为是一类新型的降糖药物,在降低血糖的同时具有许多积极作用。本研究旨在探讨SLGT2i对胃黏膜的影响。方法:观察依帕列净对48只雄性Wistar白化大鼠消炎痛性胃炎的影响。我们对胃粘膜组织进行了组织病理学评估。研究大鼠血清二硫、天然硫醇、总硫醇、缺血修饰白蛋白水平、二硫/天然硫醇比(SSSH)、天然硫醇/总硫醇百分比比(SH total SH)、二硫/总硫醇百分比比(SS total SH)。结果:我们发现依帕列净增加了大鼠胃粘膜粘蛋白的产生。此外,我们观察到,与安慰剂组相比,接受恩格列净治疗组的炎症症状较轻,胃炎评分较低。天然硫醇、总硫醇和二硫含量在消炎痛引起的胃炎组中较低。结论:本研究首次探讨了恩格列净对大鼠胃肠道的影响。我们得出结论,恩帕列净增加粘蛋白的产生,并在消炎痛诱导的胃炎模型中显示出积极的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Effects of empagliflozin against indomethacin induced gastric mucosa.

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) are considered a new class antidiabetic agent, as well as lowering blood sugar, it has many positive effects. This study aimed to investigate the effects of SLGT2i on the gastric mucosa.

Methods: We investigated the effects of empagliflozin on indomethacin-induced gastritis using 48 male Wistar Albino rats. We performed histopathological evaluations of gastric mucosa tissue. And we studied the levels of serum disulfide, native thiol, total thiol, and ischemia modified albumin, disulfide/native thiol ratio (SSSH), native thiol/total thiol percent ratio (SH total SH), and disulfide/total thiol percent ratio (SS total SH).

Results: We found that empagliflozin increased mucin production in rat gastric mucosa. Besides, we observed milder inflammation findings and lower gastritis scores in the empagliflozin receiving groups than the placebo groups. Native thiol, total thiol, and disulfide levels were lower in the indomethacin-induced gastritis groups.

Conclusions: This study is the first to investigate the effect of empagliflozin on the gastrointestinal tract in a rat model. We concluded that empagliflozin increased mucin production and revealed positive effects in an indomethacin-induced gastritis model.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.60
自引率
0.00%
发文量
146
期刊最新文献
Diet quality in patients with treatment-resistant schizophrenia: time for improving nutritional recommendations. Zebrafish model in the relentless race to tyrosine kinase inhibitors for neuroendocrine neoplasms. Assessing the impact of a dedicated referral and management algorithm in maternal hypothyroidism. Divulging the overlooked condition: diabetic ketoacidosis as an imminent risk with sodium-glucose co-transporter-2 inhibitors treatment in type 2 diabetes mellitus. Obesity prevention across the lifespan: assessing the efficacy of intervention studies and discussing future challenges.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1