恩格列净对吲哚美辛诱导的胃粘膜的影响。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-06-01 DOI:10.23736/S2724-6507.21.03425-4
Isilay Taskaldiran, Serife M Kuskonmaz, Pinar Celepli, Sema Hucumenoglu, Cemil Nural, Özcan Erel, Cavit Culha
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引用次数: 2

摘要

背景:钠-葡萄糖共转运蛋白2 (SGLT2)抑制剂(SGLT2i)被认为是一类新型的降糖药物,在降低血糖的同时具有许多积极作用。本研究旨在探讨SLGT2i对胃黏膜的影响。方法:观察依帕列净对48只雄性Wistar白化大鼠消炎痛性胃炎的影响。我们对胃粘膜组织进行了组织病理学评估。研究大鼠血清二硫、天然硫醇、总硫醇、缺血修饰白蛋白水平、二硫/天然硫醇比(SSSH)、天然硫醇/总硫醇百分比比(SH total SH)、二硫/总硫醇百分比比(SS total SH)。结果:我们发现依帕列净增加了大鼠胃粘膜粘蛋白的产生。此外,我们观察到,与安慰剂组相比,接受恩格列净治疗组的炎症症状较轻,胃炎评分较低。天然硫醇、总硫醇和二硫含量在消炎痛引起的胃炎组中较低。结论:本研究首次探讨了恩格列净对大鼠胃肠道的影响。我们得出结论,恩帕列净增加粘蛋白的产生,并在消炎痛诱导的胃炎模型中显示出积极的作用。
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Effects of empagliflozin against indomethacin induced gastric mucosa.

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) are considered a new class antidiabetic agent, as well as lowering blood sugar, it has many positive effects. This study aimed to investigate the effects of SLGT2i on the gastric mucosa.

Methods: We investigated the effects of empagliflozin on indomethacin-induced gastritis using 48 male Wistar Albino rats. We performed histopathological evaluations of gastric mucosa tissue. And we studied the levels of serum disulfide, native thiol, total thiol, and ischemia modified albumin, disulfide/native thiol ratio (SSSH), native thiol/total thiol percent ratio (SH total SH), and disulfide/total thiol percent ratio (SS total SH).

Results: We found that empagliflozin increased mucin production in rat gastric mucosa. Besides, we observed milder inflammation findings and lower gastritis scores in the empagliflozin receiving groups than the placebo groups. Native thiol, total thiol, and disulfide levels were lower in the indomethacin-induced gastritis groups.

Conclusions: This study is the first to investigate the effect of empagliflozin on the gastrointestinal tract in a rat model. We concluded that empagliflozin increased mucin production and revealed positive effects in an indomethacin-induced gastritis model.

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146
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