靶向MYC驱动的淋巴瘤:经验教训和未来方向。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2023-04-12 eCollection Date: 2023-01-01 DOI:10.20517/cdr.2022.127
Sandra Martínez-Martín, Marie-Eve Beaulieu, Laura Soucek
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引用次数: 0

摘要

MYC通过协调细胞增殖、生长和存活等转化机制在肿瘤发生中发挥核心作用。特别是,MYC经常与淋巴肿瘤有关。事实上,MYC过表达淋巴瘤,如高级别B细胞淋巴瘤(HGBL)和双表达弥漫性大B细胞淋巴瘤,被认为对MYC上瘾。在这种情况下,MYC靶向治疗特别令人感兴趣,因为MYC退出有望导致肿瘤消退。然而,高MYC水平是否总是预测对这些方法的敏感性增加,目前尚不清楚。尽管迄今为止还没有MYC抑制剂获得监管部门的批准,但已经做出了大量努力来研究使MYC成为药物靶点的途径。在这里,我们总结了目前正在开发的不同类别的分子,它们主要间接靶向侵袭性B细胞淋巴瘤中的MYC,特别关注MYC/BCL2或BCL6易位或过表达的亚型。
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Targeting MYC-driven lymphoma: lessons learned and future directions.

MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and survival, among other transformation mechanisms. In particular, MYC has often been associated with lymphomagenesis. In fact, MYC overexpressing lymphomas such as high-grade B-cell lymphoma (HGBL) and double expressor diffuse large B-cell lymphomas (DLBCL), are considered addicted to MYC. In such a context, MYC targeting therapies are of special interest, as MYC withdrawal is expected to result in tumor regression. However, whether high MYC levels are always predictive of increased sensitivity to these approaches is not clear yet. Even though no MYC inhibitor has received regulatory approval to date, substantial efforts have been made to investigate avenues to render MYC a druggable target. Here, we summarize the different classes of molecules currently under development, which mostly target MYC indirectly in aggressive B-cell lymphomas, paying special attention to subtypes with MYC/BCL2 or BCL6 translocations or overexpression.

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