中国和其他东亚祖先炎症性肠病遗传特征的最新突破。

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Precision Clinical Medicine Pub Date : 2023-08-01 DOI:10.1093/pcmedi/pbad017
Han Gao, Zhanju Liu
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引用次数: 0

摘要

炎症性肠病(IBDs)是胃肠道复杂的慢性疾病,有以下两种亚型:克罗恩病和溃疡性结肠炎。ibd内部和内部的疾病表现和进展,特别是克罗恩病,在部位、炎症的严重程度、肠狭窄和梗阻以及肠外表现方面高度不同。临床分类不能准确预测病程和对治疗的反应。迄今为止,大多数IBD遗传关联来自欧洲血统的个体,导致IBD遗传学在世界其他人群中的发现和应用受到限制。在这篇综述中,我们总结了IBD全基因组关联研究的最新进展,特别是中国人群,欧洲和东亚祖先遗传结构的异同,以及与IBD遗传研究相关的临床意义。
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The latest breakthrough on genetic characteristics of inflammatory bowel disease in Chinese and other East Asian ancestries.

Inflammatory bowel diseases (IBDs) are complex chronic disorders of the gastrointestinal tract with the following two subtypes: Crohn's disease and ulcerative colitis. Disease presentation and progression within and across IBDs, especially Crohn's disease, are highly heterogeneous in the location, severity of inflammation, intestinal stenosis and obstruction, and extraintestinal manifestations. Clinical classifications fail to accurately predict the disease course and response to therapies. To date, most IBD genetic associations are derived from individuals of European ancestries, leading to a limitation of the discovery and application of IBD genetics in the rest of the world populations. In this mini-review, we summarize the latest progress of genome-wide association studies of IBD across global ancestries especially the Chinese population, the similarities and differences in genetic architecture between European and East Asian ancestries, as well as, the clinical significances relevant to IBD genetic study.

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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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