壳聚糖衍生物作为纳米颗粒疫苗佐剂的应用。

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526522666220922102621
R Ram Narayanan, Saba Maanvizhi
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引用次数: 0

摘要

本文综述了壳聚糖衍生物作为佐剂在疫苗递送中的应用。佐剂已被用作现代疫苗的关键成分之一,以增强免疫反应或作为药物递送载体。一般来说,接种疫苗是为了保护宿主免受有害的致病传染性病原体的侵害。随着用于疫苗开发的战略和工具的演变,疫苗交付领域正日益达到新的高度。目前,疫苗已经产生了巨大的影响,挽救了许多人的生命。在PubMed和ScienceDirect的数据库中对所有相关论文进行了叙述性综述。根据在各种动物模型中进行的各种研究,壳聚糖纳米颗粒(CNP)被报道为一种安全有效的佐剂候选物,用于广泛的预防性和治疗性疫苗,这些疫苗需要平衡和有效的细胞和体液反应刺激,由于其天然来源和良好的生物相容性,以及对人类和动物缺乏致命毒性。从使用传统佐剂到使用新型佐剂,疫苗药物递送的模式发生了巨大的转变。为了开发一种有前途的疫苗递送系统,佐剂起着不可替代的作用,但由于批准的佐剂数量有限,佐剂尚未充分发挥其潜力。因此,对新型佐剂的研究大大增加。在多功能佐剂的列表中,壳聚糖衍生物因其巨大的功效占有重要的地位。通过对壳聚糖进行化学改性,得到壳聚糖衍生物。在各种动物模型上进行的研究证实了壳聚糖衍生物作为疫苗递送佐剂的潜在用途。
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Applications of Chitosan Derivatives as Adjuvant for Nanoparticles Based Vaccines.

This review focuses on the applications of chitosan derivatives towards vaccine delivery for their role as adjuvants. Adjuvants have been used as one of the key components in modern-day vaccines to enhance the immune response or as a drug delivery carrier. Generally, vaccines are administered to protect the host against harmful disease-causing infectious pathogens. The area of vaccine delivery is reaching new heights day by day with the evolution of the strategies and tools used for vaccine development. Currently, the vaccines have created a great impact by saving the lives of many human beings. A narrative review of all the relevant papers were conducted across the databases of PubMed and ScienceDirect. Based on the various studies performed in various animal models, the chitosan nanoparticle (CNP) was reported to be a safe and effective adjuvant candidate for a wide range of prophylactic and therapeutic vaccines that require a balanced and potent stimulation of both the cellular and humoral responses, due to its natural origin and good biocompatibility, as well as its lack of lethal toxicity to humans and animals. There was a tremendous shift in the paradigm of vaccine drug delivery from the use of conventional to novel adjuvants. For the development of a promising vaccine delivery system, adjuvant plays an irreplaceable role, but the adjuvants have not been utilized to their full potential because of the limited number of approved adjuvants. Hence the search for novel adjuvants is highly increased. In the list of versatile adjuvants, chitosan derivatives occupy an important place because of their huge benefits. The chitosan derivatives are obtained by the chemical modification of chitosan. The studies performed on various animal models validate the potential use of chitosan dervatives as adjuvants for vaccine delivery.

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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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