治疗更年期症状的雌激素疗法

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Best practice & research. Clinical endocrinology & metabolism Pub Date : 2024-01-01 DOI:10.1016/j.beem.2023.101789
Abbie Laing, Tim Hillard
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引用次数: 0

摘要

目的 总结治疗更年期症状的雌激素疗法的剂量选择、疗程、药代动力学、风险和益处。结果目前存在多种雌激素全身制剂,就疗效而言,它们似乎都具有可比性。它们的药代动力学各不相同,避免肝脏代谢的制剂一般风险较低,但其使用可能受到皮肤屏障或患者接受度的限制。所有阴道雌激素疗法的疗效都相当,而且没有任何健康风险。所有制剂的副作用各不相同。有多种治疗方法可供选择,临床医生的职责是指导和帮助妇女做出基于证据、公正和知情的选择。
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Oestrogen-based therapies for menopausal symptoms

Purpose

To summarise the dosing options, regimens, pharmacokinetics, risks and benefits of oestrogen-based therapies for the treatment of menopausal symptoms.

Methods

A review of the literature was undertaken using multiple databases. Randomised trials, observational studies, meta-analyses and review papers were included.

Results

Multiple systemic preparations of oestrogen exist and all appear comparable in terms of efficacy. They differ by pharmacokinetics and those preparations that avoid hepatic metabolism have a lower risk profile in general although their use can be limited by skin barriers or patient acceptability. All vaginal oestrogen treatments are comparable in efficacy and have not been associated with any health risks. Side-effects between all preparations differ.

Conclusions

With regards to oestrogen treatments there is not a one size fits all. Multiple treatments are available and a clinician’s role is to guide and help women make evidence based, unbiased and informed choices.

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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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