前哨淋巴结活检对亚洲黑色素瘤患者的生存益处。

IF 3.9 3区 医学 Q2 CELL BIOLOGY Pigment Cell & Melanoma Research Pub Date : 2023-07-19 DOI:10.1111/pcmr.13113
Che-Chia Hsu, Yi-Hua Liao, Yi-Shuan Sheen
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引用次数: 0

摘要

前哨淋巴结活检(SLNB)为早期黑色素瘤提供了重要的预后信息。然而,关于SLNB和亚洲淋巴结观察之间生存率比较的统计数据是有限的,在亚洲,肢端扁豆状黑色素瘤(ALM)占主导地位。本研究旨在确定在台湾早期黑色素瘤中,SLNB是否比淋巴结观察提供生存益处。这项回顾性研究包括227名患者,他们根据国家癌症综合网络指南符合SLNB标准,并于1997年6月至2021年6月在国立台湾大学医院接受治疗。使用Kaplan-Meier曲线和Cox比例风险回归模型进行生存分析。在研究人群中,ALM占73.1%;161例(70.9%)接受了SLNB,66例(29.1%)接受了淋巴结观察。多因素分析显示,黑色素瘤特异性生存率显著提高(危险比[HR],0.6;p = .02)。在接受完全淋巴结清扫(CLND)的患者中,非前哨淋巴结阳性率为44.4%。与淋巴结观察相比,立即CLND可显著延长黑色素瘤特异性生存期和无远处转移生存期(DMFS)。(HR,0.2;p = .01用于黑色素瘤特异性生存。HR,0.3;p = .046用于DMFS)。总之,在台湾人群中,与淋巴结观察相比,SLNB可能提供皮肤黑色素瘤的生存益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Survival benefit of sentinel lymph node biopsy in Asian melanoma patients

Sentinel lymph node biopsy (SLNB) provides important prognostic information for early-stage melanomas. However, statistics regarding the survival comparison between SLNB and nodal observation in Asia, where acral lentiginous melanoma (ALM) predominates, are limited. This study aimed to identify if SLNB offered survival benefits over nodal observation in early-stage melanomas in Taiwan. The retrospective study included 227 patients who met the SLNB criteria according to the National Comprehensive Cancer Network guidelines and were treated at National Taiwan University Hospital from June 1997 to June 2021. Survival analysis was performed using Kaplan–Meier curves and Cox proportional hazards regression models. Of the study population, ALM accounted for 73.1%; 161 patients (70.9%) underwent SLNB and 66 patients (29.1%) were under nodal observation. Multivariate analysis showed significantly improved melanoma-specific survival (hazard ratio [HR], 0.6; p = .02) in the SLNB group. Among those who underwent completion lymph node dissection (CLND), the non-sentinel node positivity rate was 44.4%. Immediate CLND resulted in significantly longer melanoma-specific survival and distant-metastasis-free survival (DMFS) compared to nodal observation. (HR, 0.2; p = .01 for melanoma-specific survival. HR, 0.3; p = .046 for DMFS). In conclusion, SLNB may provide survival benefits of cutaneous melanoma over nodal observation in the Taiwanese population.

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来源期刊
Pigment Cell & Melanoma Research
Pigment Cell & Melanoma Research 医学-皮肤病学
CiteScore
8.90
自引率
2.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders
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