非酒精性脂肪肝的脂质组学研究综述

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & metabolism Pub Date : 2023-05-01 DOI:10.1016/j.diabet.2023.101432
Sarah Béland-Bonenfant , Alexia Rouland , Jean-Michel Petit , Bruno Vergès
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引用次数: 4

摘要

非酒精性脂肪性肝病(NAFLD)包括单纯性肝脂肪变性、非酒精性脂性肝炎(NASH)和可发展为肝硬化的肝纤维化。NAFLD已成为世界许多地区慢性肝病的主要病因。脂质组学研究通过确定不同脂质种类的脂质类别浓度和脂肪酸组成,对帮助理解NAFLD的病理生理学和潜在的诊断和预后新生物标志物具有重要意义。事实上,脂质组学数据提供了与NAFLD相关的定性脂质异常的信息。我们这篇文章的目的是对NAFLD脂质组学研究的主要结果进行全面、更综合的综述。检索所有评估NAFLD患者血浆样本的人类脂质组学研究的文献。结果按肝损伤程度重新分组,包括单纯性脂肪变性、NASH或肝纤维化,并按脂质类别显示。总的来说,我们总结了与NAFLD相关的主要脂质组学异常如下:游离脂肪酸分布的改变、神经酰胺的增加、磷脂酰胆碱/磷脂酰乙醇胺比率的降低以及类花生酸的增加。这些脂质异常可能通过诱导线粒体功能障碍、细胞凋亡、炎症、氧化和内质网应激来促进NASH和肝纤维化。尽管这些脂质组学异常在许多研究中都有报道,但还需要进一步的研究来阐明它们是否可以预测肝脂肪变性、NASH或肝纤维化。
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Concise review of lipidomics in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) encompasses simple liver steatosis, nonalcoholic steatohepatitis (NASH), and liver fibrosis that can progress to cirrhosis. NAFLD has become the principal cause of chronic liver disease in many parts of the world. Lipidomic studies, by allowing to determine concentrations of lipid classes and fatty acid composition of different lipid species, have been of great interest to help understand NAFLD pathophysiology and potentially identify novel biomarkers for diagnosis and prognosis. Indeed, lipidomic data give information on qualitative lipid abnormalities associated with NAFLD. The aim of our article was to create a comprehensive and more synthetic review of main results from lipidomic studies in NAFLD. Literature was searched for all human lipidomic studies evaluating plasma samples of individuals with NAFLD. Results were regrouped by the degree of liver damage, either simple steatosis, NASH or liver fibrosis, and presented by lipid categories. Overall, we summarized the main lipidomic abnormalities associated with NAFLD as follows: modification of free fatty acid distribution, increase in ceramides, reduced phosphatidylcholine / phosphatidylethanolamine ratio, and increase in eicosanoids. These lipid abnormalities are likely to promote NASH and liver fibrosis by inducing mitochondrial dysfunction, apoptosis, inflammation, oxidation, and endoplasmic reticulum stress. Although these lipidomic abnormalities are consistently reported in many studies, further research is needed to clarify whether they may be predictive for liver steatosis, NASH or liver fibrosis.

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来源期刊
Diabetes & metabolism
Diabetes & metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.20%
发文量
86
审稿时长
13 days
期刊介绍: A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
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