寄生线虫在易感但不耐药的腹足类宿主中诱导生态失调

IF 3.9 3区 生物学 Q2 MICROBIOLOGY MicrobiologyOpen Pub Date : 2023-03-10 DOI:10.1002/mbo3.1346
Laura Sheehy, Kerry MacDonald-Howard, Chris D. Williams, Gareth D. Weedall, Hayley Jones, Robbie Rae
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引用次数: 1

摘要

动物的肠道微生物组影响广泛的生物过程,包括免疫和对病原体的保护。然而,微生物组如何因寄生虫感染而发生变化在很大程度上仍然是未知的,微生物组如何在对寄生虫易感性不同的宿主中发生变化也是未知的。为了研究这一点,我们暴露了两种对两性寄生线虫Phasmarhabditis hermaphrodita敏感程度不同的蛞蝓(Deroceras reticulatum对该线虫高度敏感,而Ambigolimax valentianus对该线虫有抗性),并在7天和14天后对其肠道微生物群进行了分析。在感染前,这两种蛞蝓的微生物群都以相似的细菌属为主:假单胞菌(迄今为止数量最多)、鞘菌、土杆菌、黄杆菌和黄杆菌。在抗性寄主a . valentianus中,感染后细菌属无明显变化,但在网纹田鼠中,细菌谱发生了变化,感染后7 d,假单胞菌科丰度下降,黄杆菌科和鞘菌科丰度增加。这表明线虫感染导致易受感染的宿主生态失调,但耐药物种的微生物组保持不变。综上所述,免疫系统的调节与宿主生存密切相关,而线虫感染可以改变微生物组结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A parasitic nematode induces dysbiosis in susceptible but not resistant gastropod hosts

Animals’ gut microbiomes affect a wide array of biological processes including immunity and protection from pathogens. However, how the microbiome changes due to infection by parasites is still largely unknown, as is how the microbiome changes in hosts that differ in their susceptibility to parasites. To investigate this, we exposed two slug species of differing susceptibility to the parasitic nematode Phasmarhabditis hermaphrodita (Deroceras reticulatum is highly susceptible and Ambigolimax valentianus resistant to the nematode) and profiled the gut microbiota after 7 and 14 days. Before infection, both slug species’ microbiota was dominated by similar bacterial genera: Pseudomonas (by far the most abundant), Sphingobacterium, Pedobacter, Chryseobacterium, and Flavobacterium. In the resistant host A. valentianus, there was no significant change in the bacterial genera after infection, but in D. reticulatum, the bacterial profile changed, with a decrease in the abundance of Pseudomonadaceae and an increase in the abundance of Flavobacteriaceae and Sphingobacteriaceae after 7 days postinfection. This suggests nematode infection causes dysbiosis in hosts that are susceptible to infection, but the microbiome of resistant species remains unaltered. In summary, the regulation of the immune system is tightly linked with host survival, and nematode infection can alter the microbiome structure.

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来源期刊
MicrobiologyOpen
MicrobiologyOpen MICROBIOLOGY-
CiteScore
8.00
自引率
0.00%
发文量
78
审稿时长
20 weeks
期刊介绍: MicrobiologyOpen is a peer reviewed, fully open access, broad-scope, and interdisciplinary journal delivering rapid decisions and fast publication of microbial science, a field which is undergoing a profound and exciting evolution in this post-genomic era. The journal aims to serve the research community by providing a vehicle for authors wishing to publish quality research in both fundamental and applied microbiology. Our goal is to publish articles that stimulate discussion and debate, as well as add to our knowledge base and further the understanding of microbial interactions and microbial processes. MicrobiologyOpen gives prompt and equal consideration to articles reporting theoretical, experimental, applied, and descriptive work in all aspects of bacteriology, virology, mycology and protistology, including, but not limited to: - agriculture - antimicrobial resistance - astrobiology - biochemistry - biotechnology - cell and molecular biology - clinical microbiology - computational, systems, and synthetic microbiology - environmental science - evolutionary biology, ecology, and systematics - food science and technology - genetics and genomics - geobiology and earth science - host-microbe interactions - infectious diseases - natural products discovery - pharmaceutical and medicinal chemistry - physiology - plant pathology - veterinary microbiology We will consider submissions across unicellular and cell-cluster organisms: prokaryotes (bacteria, archaea) and eukaryotes (fungi, protists, microalgae, lichens), as well as viruses and prions infecting or interacting with microorganisms, plants and animals, including genetic, biochemical, biophysical, bioinformatic and structural analyses. The journal features Original Articles (including full Research articles, Method articles, and Short Communications), Commentaries, Reviews, and Editorials. Original papers must report well-conducted research with conclusions supported by the data presented in the article. We also support confirmatory research and aim to work with authors to meet reviewer expectations. MicrobiologyOpen publishes articles submitted directly to the journal and those referred from other Wiley journals.
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