血浆S100A8和S100A9是乙型肝炎病毒相关急慢性肝衰竭的重要预后因素

IF 2.7 4区医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2023-01-01 DOI:10.1155/2023/6164611

Yao Zhang, Xueyun Zhang, Jiajia Han, Yifei Guo, Jingjing He, Feifei Yang, Richeng Mao, Yuxian Huang, Jiming Zhang

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引用次数: 0

摘要

目的:急性慢性肝衰竭(ACLF)快速发展的器官衰竭和高短期死亡率与全身炎症反应的作用是分不开的。S100A8和S100A9与过度的细胞因子风暴有关，在炎症过程中起决定性作用。我们的目的是阐明它们在预测乙型肝炎病毒相关ACLF (HBV-ACLF)预后中的作用。方法:对187例无移植HBV-ACLF患者、28例健康对照和40例慢性乙型肝炎(CHB)患者血浆中S100A8和S100A9水平进行分析。我们在32例HBV-ACLF肝移植患者、19例肝血管瘤手术患者和10例CHB穿刺活检患者的肝脏样本中检测了S100A8和S100A9 mrna。结果:HBV-ACLF患者血浆中S100A8和S100A9水平高于CHB患者(S100A8: P < 0.001和S100A9: P < 0.001)和健康对照组(S100A8: P < 0.001和S100A9: P < 0.001)， mRNA表达结果相似。此外，这两种蛋白都与ACLF分级、不同类型的器官衰竭和感染有关，并与其他预后评分系统相关。S100A8和S100A9能独立预测28/90天死亡率(28天:S100A8:风险比(HR): 1.027;95%置信区间(CI): 1.007-1.048;P=0.026, s100a9; hr: 1.009;95% ci: 1.001-1.017;P=0.007, 90天:S100A8: HR: 1.023;95% ci: 1.011-1.035;P=0.004, s100a9; hr: 1.008;95% ci: 1.004-1.012;P < 0.001)。在所有评分系统中，联合评分模型(S100A8和S100A9联合慢性肝功能衰竭-联合脏器功能衰竭评分(clifc - OFs))在预测90天死亡率时，受试者工作曲线下面积最大(0.923 (95% CI, 0.887-0.961))。结论:S100A8和S100A9是分析ACLF患者风险分层和预后的有希望的生物标志物。此外，将其与CLIF-C OFs相结合可以更好地预测ACLF的预后。

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Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Objectives: The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF (HBV-ACLF).

Methods: S100A8 and S100A9 levels were analyzed in plasma of 187 transplant-free HBV-ACLF patients, 28 healthy controls and 40 chronic hepatitis B (CHB) patients. S100A8 and S100A9 mRNAs were checked in liver samples from 32 HBV-ACLF patients with liver transplantation, 19 patients undergoing surgery for hepatic hemangioma and 10 CHB patients with needle biopsy.

Results: The plasma levels of the S100A8 and S100A9 were higher in HBV-ACLF patients than in CHB patients (S100A8 : P < 0.001 and S100A9 : P < 0.001) and healthy controls (S100A8 : P < 0.001 and S100A9 : P < 0.001), and similar results were obtained for mRNA expression. Moreover, both proteins were related to ACLF grade, different types of organ failure, and infection, and they correlated with other prognostic scoring systems. S100A8 and S100A9 can dependently predict 28/90-day mortality (28-day: S100A8: hazard ratio (HR): 1.027; 95% confidence interval (CI): 1.007-1.048; P=0.026, S100A9 : HR: 1.009; 95% CI: 1.001-1.017; P=0.007, 90-day: S100A8 : HR: 1.023; 95% CI: 1.011-1.035; P=0.004, S100A9 : HR: 1.008; 95% CI: 1.004-1.012; and P < 0.001). Among all of the scoring systems, the combined scoring model (S100A8 and S100A9 jointly with the Chronic Liver Failure-Consortium Organ Failure score (CLIF-C OFs)) displayed the highest area under the receiver operating curve (0.923 (95% CI, 0.887-0.961)) in the prediction of 90-day mortality.

Conclusions: S100A8 and S100A9 are promising biomarkers for the analysis of risk stratification and prognosis in ACLF patients. In addition, combining them with the CLIF-C OFs may better predict the prognosis of ACLF.

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来源期刊

Canadian Journal of Gastroenterology and Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

37 weeks

期刊介绍： Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.