Charlotte Steenblock (Principal Investigator in Endocrinology) , Nicole Toepfner (Senior Clinical Scientist in Paediatric Infectious Diseases) , Felix Beuschlein (Professor in Endocrinology and Head of Department) , Nikolaos Perakakis (Professor of Metabolic and Vascular Medicine) , Ranjit Mohan Anjana (Vice President & Managing Director) , Viswanathan Mohan (Director & Chief of Diabetes Research) , Nitish R. Mahapatra (Professor) , Stefan R. Bornstein (Professor & Clinic Director)
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The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunction, such as hyperglycaemia or in rare cases, new-onset diabetes. Furthermore, an infection with SARS-CoV-2 may have indirect effects affecting the endocrine system. The exact mechanisms are not yet completely understood and have to be further investigated. Conversely, endocrine diseases may affect the severity of COVID-19 and emphasis has to be laid on reducing the prevalence, or enhance the treatment, of these often non-communicable diseases in the future.</p></div>","PeriodicalId":8810,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":"37 4","pages":"Article 101761"},"PeriodicalIF":6.1000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985546/pdf/","citationCount":"4","resultStr":"{\"title\":\"SARS-CoV-2 infection and its effects on the endocrine system\",\"authors\":\"Charlotte Steenblock (Principal Investigator in Endocrinology) , Nicole Toepfner (Senior Clinical Scientist in Paediatric Infectious Diseases) , Felix Beuschlein (Professor in Endocrinology and Head of Department) , Nikolaos Perakakis (Professor of Metabolic and Vascular Medicine) , Ranjit Mohan Anjana (Vice President & Managing Director) , Viswanathan Mohan (Director & Chief of Diabetes Research) , Nitish R. Mahapatra (Professor) , Stefan R. 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SARS-CoV-2 infection and its effects on the endocrine system
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) can infect multiple tissues, including endocrine organs, such as the pancreas, adrenal, thyroid, and adipose tissue. The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunction, such as hyperglycaemia or in rare cases, new-onset diabetes. Furthermore, an infection with SARS-CoV-2 may have indirect effects affecting the endocrine system. The exact mechanisms are not yet completely understood and have to be further investigated. Conversely, endocrine diseases may affect the severity of COVID-19 and emphasis has to be laid on reducing the prevalence, or enhance the treatment, of these often non-communicable diseases in the future.
期刊介绍：
Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management.
Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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