自主神经系统失调和骨关节炎疼痛:机制、测量和未来展望。

IF 5.7 2区 医学 Q1 RHEUMATOLOGY Current Rheumatology Reports Pub Date : 2022-06-01 DOI:10.1007/s11926-022-01071-9
Taylor D Yeater, Carlos J Cruz, Yenisel Cruz-Almeida, Kyle D Allen
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引用次数: 10

摘要

综述目的:自主神经系统是应激反应的重要调节因子,在慢性疼痛状态下表现出功能改变。这篇综述讨论了自主神经失调、骨关节炎(OA)进展和慢性疼痛之间的潜在重叠。在此基础上,我们讨论临床前到临床研究的机会,以缩小我们在自主神经失调和OA方面的知识差距。最后,我们考虑通过调节自主神经系统产生OA疼痛新疗法的潜力。最近的研究发现:最近的综述为OA进展中的自主神经系统提供了一个框架;然而,关于这一主题的研究仍然有限。在其他慢性疼痛状态中,中枢自主神经网络和大脑疼痛处理中心之间的功能重叠表明这两个系统的共同失调之间存在关系。非药物治疗,如迷走神经刺激、基于正念的冥想和运动,在减轻关节疾病的疼痛症状方面显示出希望,这些干预可能部分通过自主神经系统介导。自主神经系统似乎在OA进展中失调,进一步研究重新平衡自主神经功能可能会导致治疗OA疼痛的新治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.

Purpose of review: The autonomic nervous system is an important regulator of stress responses and exhibits functional changes in chronic pain states. This review discusses potential overlap among autonomic dysregulation, osteoarthritis (OA) progression, and chronic pain. From this foundation, we then discuss preclinical to clinical research opportunities to close gaps in our knowledge of autonomic dysregulation and OA. Finally, we consider the potential to generate new therapies for OA pain via modulation of the autonomic nervous system.

Recent findings: Recent reviews provide a framework for the autonomic nervous system in OA progression; however, research is still limited on the topic. In other chronic pain states, functional overlaps between the central autonomic network and pain processing centers in the brain suggest relationships between concomitant dysregulation of the two systems. Non-pharmacological therapeutics, such as vagus nerve stimulation, mindfulness-based meditation, and exercise, have shown promise in alleviating painful symptoms of joint diseases, and these interventions may be partially mediated through the autonomic nervous system. The autonomic nervous system appears to be dysregulated in OA progression, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
期刊最新文献
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