甲状腺肿瘤发生中的脱碘酶。

IF 4.1 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine-related cancer Pub Date : 2023-05-01 DOI:10.1530/ERC-23-0015
Maria Angela De Stefano, Tommaso Porcelli, Martin Schlumberger, Domenico Salvatore
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引用次数: 0

摘要

三种脱碘酶硒酶是细胞内甲状腺激素(TH)水平的关键调节因子。两种促甲状腺素脱碘酶(1型脱碘酶和2型脱碘酶(D2))通常在滤泡甲状腺细胞中表达,并参与促甲状腺素的产生。在甲状腺肿瘤发生过程中,脱碘酶表达谱发生变化,使细胞内TH水平适应癌细胞的不同需要。分化型甲状腺癌过表达灭活TH的3型脱碘酶(D3),可能降低肿瘤内的TH信号。引人注目的是,最近的证据表明,在甲状腺肿瘤发生的晚期,D2表达升高,这与D3表达水平的降低一起,增加了去分化甲状腺癌中TH细胞内信号传导。这些发现对甲状腺素在甲状腺癌不同阶段的不同功能提出了质疑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Deiodinases in thyroid tumorigenesis.

The three deiodinase selenoenzymes are key regulators of intracellular thyroid hormone (TH) levels. The two TH-activating deiodinases (type 1 deiodinase and type 2 deiodinase (D2)) are normally expressed in follicular thyroid cells and contribute to overall TH production. During thyroid tumorigenesis, the deiodinase expression profile changes to customize intracellular TH levels to different requirements of cancer cells. Differentiated thyroid cancers overexpress the TH-inactivating type 3 deiodinase (D3), likely to reduce the TH signaling within the tumor. Strikingly, recent evidence suggests that during the late stage of thyroid tumorigenesis, D2 expression raises and this, together with a reduction in D3 expression levels, increases TH intracellular signaling in dedifferentiated thyroid cancers. These findings call into question the different functions of TH in the various stages of thyroid cancers.

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来源期刊
Endocrine-related cancer
Endocrine-related cancer 医学-内分泌学与代谢
CiteScore
7.80
自引率
2.60%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Endocrine-Related Cancer is an official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, the United Kingdom and Ireland Neuroendocrine Society, and the Japanese Hormones and Cancer Society. Endocrine-Related Cancer provides a unique international forum for the publication of high quality original articles describing novel, cutting edge basic laboratory, translational and clinical investigations of human health and disease focusing on endocrine neoplasias and hormone-dependent cancers; and for the publication of authoritative review articles in these topics. Endocrine neoplasias include adrenal cortex, breast, multiple endocrine neoplasia, neuroendocrine tumours, ovary, prostate, paraganglioma, parathyroid, pheochromocytoma pituitary, testes, thyroid and hormone-dependent cancers. Neoplasias affecting metabolism and energy production such as bladder, bone, kidney, lung, and head and neck, are also considered.
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