Adil Qabouche, Ayoub Amssayef, Ismail Bouadid, Nadia Lahrach, Ahmed El-Haidani, Mohamed Eddouks
{"title":"摩洛哥特有植物马先蒿的抗糖尿病和血脂异常作用。","authors":"Adil Qabouche, Ayoub Amssayef, Ismail Bouadid, Nadia Lahrach, Ahmed El-Haidani, Mohamed Eddouks","doi":"10.2174/1871529X23666230803113616","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The study aimed to assess the antihyperglycemic and antidyslipidemic activities of <i>Artemisia mesatlantica</i>.</p><p><strong>Background: </strong><i>Artemisia mesatlantica</i> is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.</p><p><strong>Objective: </strong>The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of <i>Artemisia mesatlantica</i> (AMAE) in experimental animal models.</p><p><strong>Methods: </strong>The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of <i>Artemisia mesatlantica</i>, a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.</p><p><strong>Results: </strong>The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of <i>Artemisia mesatlantica</i> (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.</p><p><strong>Conclusion: </strong>From these observed results, it can be deduced that <i>Artemisia mesatlantica</i> possesses remarkable antidiabetic and antihyperlipidemic properties.</p>","PeriodicalId":9543,"journal":{"name":"Cardiovascular and Hematological Disorders - Drug Targets","volume":" ","pages":"50-63"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antidiabetic and Antidyslipidemic Effects of <i>Artemisia mesatlantica</i>, an Endemic Plant from Morocco.\",\"authors\":\"Adil Qabouche, Ayoub Amssayef, Ismail Bouadid, Nadia Lahrach, Ahmed El-Haidani, Mohamed Eddouks\",\"doi\":\"10.2174/1871529X23666230803113616\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>The study aimed to assess the antihyperglycemic and antidyslipidemic activities of <i>Artemisia mesatlantica</i>.</p><p><strong>Background: </strong><i>Artemisia mesatlantica</i> is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.</p><p><strong>Objective: </strong>The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of <i>Artemisia mesatlantica</i> (AMAE) in experimental animal models.</p><p><strong>Methods: </strong>The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of <i>Artemisia mesatlantica</i>, a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.</p><p><strong>Results: </strong>The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of <i>Artemisia mesatlantica</i> (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.</p><p><strong>Conclusion: </strong>From these observed results, it can be deduced that <i>Artemisia mesatlantica</i> possesses remarkable antidiabetic and antihyperlipidemic properties.</p>\",\"PeriodicalId\":9543,\"journal\":{\"name\":\"Cardiovascular and Hematological Disorders - Drug Targets\",\"volume\":\" \",\"pages\":\"50-63\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular and Hematological Disorders - Drug Targets\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1871529X23666230803113616\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular and Hematological Disorders - Drug Targets","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871529X23666230803113616","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an Endemic Plant from Morocco.
Aims: The study aimed to assess the antihyperglycemic and antidyslipidemic activities of Artemisia mesatlantica.
Background: Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.
Objective: The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models.
Methods: The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.
Results: The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.
Conclusion: From these observed results, it can be deduced that Artemisia mesatlantica possesses remarkable antidiabetic and antihyperlipidemic properties.
期刊介绍:
Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.