iPSC衍生的心血管疾病模型中的靶向cAMP信号区

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY Current Opinion in Pharmacology Pub Date : 2023-08-01 DOI:10.1016/j.coph.2023.102392

Tiannan Liu , Enno Klussmann

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引用次数: 0

摘要

腺苷3′，5′-环磷酸（cAMP）作为第二信使参与过多过程的调节。cAMP信号在特定区室中的激活对于细胞以特定方式对细胞外刺激作出反应至关重要。人类诱导多能干细胞（iPSC）领域的快速发展反映了其在心血管疾病建模、药物筛选、再生和精准医学方面的巨大潜力。这篇综述讨论了iPSC衍生的心血管疾病模型中的cAMP信号，以及使用这些系统来阐明疾病机制、药物作用和确定治疗未满足医疗需求的心血管疾病（如高血压和心力衰竭）的新药物靶点的前景。

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Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease

Adenosine 3′,5′-cyclic monophosphate (cAMP) acts as a second messenger that is involved in the regulation of a plethora of processes. The activation of cAMP signaling in defined compartments is critical for cells to respond to an extracellular stimulus in a specific manner. Rapid advances in the field of human induced pluripotent stem cells (iPSCs) reflect their great potential for cardiovascular disease modeling, drug screening, regenerative and precision medicine. This review discusses cAMP signaling in iPSC-derived cardiovascular disease models, and the prospects of using such systems to elucidate disease mechanisms, drug actions and to identify novel drug targets for the treatment of cardiovascular diseases with unmet medical need, such as hypertension and heart failure.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.