Dana Voinier, Tuhina Neogi, Hiral Master, Louise M Thoma, Meredith Brunette, Jason Jakiela, Joshua J Stefanik, Daniel K White
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We examined the association of leisure-time sitting (≤4 vs. >4 h/day) with risk of radiographic knee OA incidence/progression using binary linear regression, adjusting for potential confounders. We stratified by worktime sitting (frequent vs. infrequent) and repeated our analysis.</p><p><strong>Results: </strong>We included 4254 adults (mean age 61 years; 58% women; mean body mass index 29 kg/m<sup>2</sup> ) who contributed a total of 8127 knees. Adults with >4 h/day of leisure-time sitting had 25% higher risk (adjusted risk ratio [RR] 1.25, 95% confidence interval [95% CI] 1.08-1.50) for radiographic knee OA incidence/progression compared with adults with ≤4 h/day of leisure-time sitting (referent group). Importantly, this association was intensified (RR 1.60, 95% CI 1.19-2.33) among adults with frequent worktime sitting, but was attenuated (RR 1.11, 95% CI 0.89-1.39) among adults with infrequent worktime sitting.</p><p><strong>Conclusions: </strong>Higher leisure-time sitting (>4 h/day) may be associated with greater risk for radiographic knee OA incidence/progression over 2 years. Furthermore, this association was intensified among adults who also reported frequent worktime sitting.</p>","PeriodicalId":46945,"journal":{"name":"Musculoskeletal Care","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687316/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study.\",\"authors\":\"Dana Voinier, Tuhina Neogi, Hiral Master, Louise M Thoma, Meredith Brunette, Jason Jakiela, Joshua J Stefanik, Daniel K White\",\"doi\":\"10.1002/msc.1786\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To examine the association of leisure-time sitting with radiographic incidence and progression of knee osteoarthritis (OA) over 2 years, and to determine whether worktime sitting modifies this association.</p><p><strong>Methods: </strong>We included adults with or at high risk for knee OA who enroled in the Osteoarthritis Initiative (OAI). Participants reported leisure-time sitting (≤4 vs. >4 h/day) and worktime sitting (frequent vs. infrequent) at enrolment, and had bilateral knee radiographs at enrolment and 2 years later. Our outcome, radiographic knee OA incidence/progression (yes/no), was defined as any increase in Kellgren-Lawrence grade over 2 years. We examined the association of leisure-time sitting (≤4 vs. >4 h/day) with risk of radiographic knee OA incidence/progression using binary linear regression, adjusting for potential confounders. We stratified by worktime sitting (frequent vs. infrequent) and repeated our analysis.</p><p><strong>Results: </strong>We included 4254 adults (mean age 61 years; 58% women; mean body mass index 29 kg/m<sup>2</sup> ) who contributed a total of 8127 knees. 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引用次数: 0
摘要
目的:研究休闲时间久坐与2年以上膝骨关节炎(OA)的放射学发病率和进展之间的关系,并确定工作时间久坐是否改变了这种关系。方法:我们纳入了参加骨关节炎倡议(OAI)的患有或有膝关节OA高风险的成年人。参与者在入组时报告了休闲时间坐着(≤4小时/天vs >4小时/天)和工作时间坐着(频繁vs不频繁),并在入组时和2年后进行了双侧膝关节x线片检查。我们的结果,膝关节OA的放射学发病率/进展(是/否),被定义为2年内kelgren - lawrence分级的任何增加。我们使用二元线性回归检查了休闲时间坐着(≤4小时vs >4小时/天)与膝关节OA放射学发病率/进展风险的关系,并调整了潜在的混杂因素。我们根据工作时间坐着(频繁与不频繁)进行了分层,并重复了我们的分析。结果:我们纳入了4254名成人(平均年龄61岁;58%的女性;平均身体质量指数29 kg/m2)者共贡献8127个膝关节。与休闲时间坐着≤4小时/天的成年人(参照组)相比,休闲时间坐着>4小时/天的成年人膝关节炎的放射学发病率/进展风险增加25%(调整风险比[RR] 1.25, 95%可信区间[95% CI] 1.08-1.50)。重要的是,在工作时间经常坐着的成年人中,这种关联增强(RR 1.60, 95% CI 1.19-2.33),但在工作时间不经常坐着的成年人中,这种关联减弱(RR 1.11, 95% CI 0.89-1.39)。结论:休闲时间久坐(>4小时/天)可能与2年内膝关节骨性关节炎发病率/进展的更高风险相关。此外,这种关联在工作时间经常坐着的成年人中更为明显。
Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study.
Objectives: To examine the association of leisure-time sitting with radiographic incidence and progression of knee osteoarthritis (OA) over 2 years, and to determine whether worktime sitting modifies this association.
Methods: We included adults with or at high risk for knee OA who enroled in the Osteoarthritis Initiative (OAI). Participants reported leisure-time sitting (≤4 vs. >4 h/day) and worktime sitting (frequent vs. infrequent) at enrolment, and had bilateral knee radiographs at enrolment and 2 years later. Our outcome, radiographic knee OA incidence/progression (yes/no), was defined as any increase in Kellgren-Lawrence grade over 2 years. We examined the association of leisure-time sitting (≤4 vs. >4 h/day) with risk of radiographic knee OA incidence/progression using binary linear regression, adjusting for potential confounders. We stratified by worktime sitting (frequent vs. infrequent) and repeated our analysis.
Results: We included 4254 adults (mean age 61 years; 58% women; mean body mass index 29 kg/m2 ) who contributed a total of 8127 knees. Adults with >4 h/day of leisure-time sitting had 25% higher risk (adjusted risk ratio [RR] 1.25, 95% confidence interval [95% CI] 1.08-1.50) for radiographic knee OA incidence/progression compared with adults with ≤4 h/day of leisure-time sitting (referent group). Importantly, this association was intensified (RR 1.60, 95% CI 1.19-2.33) among adults with frequent worktime sitting, but was attenuated (RR 1.11, 95% CI 0.89-1.39) among adults with infrequent worktime sitting.
Conclusions: Higher leisure-time sitting (>4 h/day) may be associated with greater risk for radiographic knee OA incidence/progression over 2 years. Furthermore, this association was intensified among adults who also reported frequent worktime sitting.
期刊介绍:
Musculoskeletal Care is a peer-reviewed journal for all health professionals committed to the clinical delivery of high quality care for people with musculoskeletal conditions and providing knowledge to support decision making by professionals, patients and policy makers. This journal publishes papers on original research, applied research, review articles and clinical guidelines. Regular topics include patient education, psychological and social impact, patient experiences of health care, clinical up dates and the effectiveness of therapy.