膀胱癌中 MTHFD 家族的表达、预后价值和免疫渗透

IF 2.3 4区医学 Q3 ONCOLOGY Current cancer drug targets Pub Date : 2024-01-01 DOI:10.2174/1568009623666230804152603

Bai Shu Zheng, Shun De Wang, Jun Yong Zhang, Cheng Guo Ge

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引用次数: 0

摘要

背景：亚甲基四氢叶酸脱氢酶（MTHFD）家族在多种肿瘤的发展和预后中发挥着重要作用；然而，MTHFD家族在膀胱癌中的作用尚不清楚：方法：使用 R 软件、cBioPortal、GeneMANIA 和 String-LinkedOmics 等在线网站进行生物信息学分析：结果：与正常组织相比，MTHFD1/1L/2在膀胱癌组织中明显上调，MTHFD家族的高表达与较差的临床分级和分期密切相关，MTHFD1L/2上调的膀胱癌患者预后明显较差。基因功能和PPI网络分析显示，MTHFD家族和相关基因在膀胱癌的发生发展中起着协同作用。800个与MTHFD家族相关的共表达基因被用于功能富集分析，结果显示许多基因与细胞周期和DNA复制等多种致癌途径相关。更重要的是，MTHFD家族与包括Treg细胞在内的多种浸润性免疫淋巴细胞以及TNFSF9、CD274和PDCD1等免疫分子密切相关：我们的研究表明，MTHFD家族基因可能是膀胱癌患者的潜在预后标志物和治疗靶点。

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Expression, Prognostic Value, and Immune Infiltration of MTHFD Family in Bladder Cancer.

Background: The Methylenetetrahydrofolate Dehydrogenase (MTHFD) family plays an important role in the development and prognosis of a variety of tumors; however, the role of the MTHFD family in bladder cancer is unclear.

Methods: R software, cBioPortal, GeneMANIA, and online sites such as String-LinkedOmics were used for bioinformatics analysis.

Results: MTHFD1/1L/2 was significantly upregulated in bladder cancer tissues compared with normal tissues, high expression of the MTHFD family was strongly associated with poorer clinical grading and staging, and bladder cancer patients with upregulated expression of MTHFD1L/2 had a significantly worse prognosis. Gene function and PPI network analysis revealed that the MTHFD family and related genes play synergistic roles in the development of bladder cancer. 800 co-expressed genes related to the MTHFD family were used for functional enrichment analysis, and the results showed that many genes were associated with various oncogenic pathways such as cell cycle and DNA replication. More importantly, the MTHFD family was closely associated with multiple infiltrating immune lymphocytes, including Treg cells, and immune molecules such as TNFSF9, CD274, and PDCD1.

Conclusion: Our study shows that MTHFD family genes may be potential prognostic markers and therapeutic targets for patients with bladder cancer.

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.