抗生素使用和癌症风险交叉路口的新见解。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2023-06-01 DOI:10.15698/cst2023.06.280
Nermina Malanovic, Djenana Vejzovic
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引用次数: 1

摘要

持续使用抗生素与抗菌素耐药性的扩散有关,与癌症发展的联系尚不清楚。许多传统抗生素已经对各种癌症类型显示出不同的效果,这对它们在癌症中的合理使用提出了疑问。然而,观察到的一些抗生素减少癌症发展并与更高癌症风险相关的趋势存在差异,这突显了对抗生素与癌症之间复杂联系的了解不足。在这里,我们简要总结了可能的抗生素对癌症的介导作用,并得出结论,这些作用可以直接通过i)肿瘤/癌症的特异性靶向,ii)抗菌活性和iii)免疫调节活性,其中iv)间接引起的作用主要影响细菌,癌症和免疫细胞之间的免疫平衡。此外,我们还得出结论,所有国家都非常需要进行大量分析,全面筛选计划和深入研究,以了解抗生素使用的风险和益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Novel insights at the crossroads of antibiotic use and cancer risk.

The continuous use of antibiotics is associated with the spread of antimicrobial resistances and the not yet clear link to cancer development. Many conventional antibiotics have already shown different effects on a variety of cancer types raising questions for their rational use in cancer. However, discrepancy in the observed trend for some antibiotics reducing cancer development and being associated with higher risk of cancer underscores the lack of understanding the complex link between antibiotics and cancer. Here, we briefly summarize the possible antibiotic-mediated effects on cancer and conclude that those effects can be direct via i) specific targeting of tumor/cancer, ii) antimicrobial activity and iii) immunomodulatory activity whereby iv) indirectly caused effects primarily affect immune equilibrium between bacteria, cancer and immune cells. Furthermore, we also conclude that there is a great need for bulk profiling, comprehensive screening programs in all countries and in-depth studies to understand the risks and benefits of antibiotic use.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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