组织淋巴细胞/嗜酸性粒细胞比值预测嗜酸性CRSwNP的长期复发。

IF 2.5 3区 医学 Q1 OTORHINOLARYNGOLOGY American Journal of Rhinology & Allergy Pub Date : 2023-09-01 DOI:10.1177/19458924231179615
Jianwei Wang, Yujuan Yang, Jing Guo, Pengyi Yu, Guangkuo Wang, Xinyue Liu, Zheng Zhang, Tong Li, Yu Zhang, Xicheng Song
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引用次数: 1

摘要

背景:嗜酸性慢性鼻窦炎伴鼻息肉(Eos-CRSwNP)是一种顽固性疾病,复发率高。目的:本研究旨在确定Eos-CRSwNP患者长期复发的预测因子。方法:回顾性研究39例手术切除的首发和复发性鼻息肉Eos-CRSwNP患者,其中49例无复发的Eos-CRSwNP患者和32例非Eos-CRSwNP患者随机配对。比较两组间及组间临床特征。采用Spearman相关分析和多元逐步logistic回归分析,寻找与Eos-CRSwNP复发及复发时间相关的因素。此外,使用受试者工作特征(ROC)曲线来确定长期Eos-CRSwNP复发的预测因子。结果:组织嗜酸性粒细胞的数量和比例在复发的Eos-CRSwNP中最高,在非Eos-CRSwNP中最低。组织淋巴细胞比例以非Eos-CRSwNP组最高,有复发的Eos-CRSwNP组最低,无复发的Eos-CRSwNP组组织淋巴细胞数量高于其他两组。术后>5年复发鼻息肉组与术后5年复发鼻息肉组相比,初始鼻息肉组织淋巴细胞数量较低,组织嗜酸性粒细胞数量较高。结论:组织LER与Eos-CRSwNP复发密切相关,可能在预测长期Eos-CRSwNP复发中起关键作用。
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The Tissue Lymphocyte-to-Eosinophil Ratio Predicted Long-Term Recurrence of Eosinophilic CRSwNP.

Background: Eosinophilic chronic rhinosinusitis with nasal polyps (Eos-CRSwNP) remains a recalcitrant disease with a high recurrence rate.

Objective: This study aimed to identify a predictor of long-term recurrence in patients with Eos-CRSwNP.

Methods: A total of 39 Eos-CRSwNP patients who had their initial and recurrent nasal polyps surgically removed were retrospectively included in this study, with 49 Eos-CRSwNP patients without recurrence and 32 patients with non-Eos-CRSwNP matched by randomly chosen. Clinical characteristics were compared among or between groups. Spearman correlation analyses and a backward stepwise multivariate logistic regression analysis were performed to find factors associated with the recurrence and recurrence time of Eos-CRSwNP. Furthermore, a receiver operating characteristic (ROC) curve was used to determine the predictor of long-term Eos-CRSwNP recurrence.

Results: The number and ratio of tissue eosinophils were highest in Eos-CRSwNP with recurrence and lowest in non-Eos-CRSwNP. The ratio of tissue lymphocytes was highest in non-Eos-CRSwNP and lowest in Eos-CRSwNP with recurrence, with the number of tissue lymphocytes higher in Eos-CRSwNP without recurrence than the other two groups. The numbers of tissue lymphocytes in the initial nasal polyps were lower and the numbers of tissue eosinophils were higher in the group of recurrent nasal polyps that recurred at >5 years after surgery than in the nasal polyps that recurred at <5 years after surgery. The tissue lymphocyte-to-eosinophil ratio (LER) showed a significant negative correlation with the recurrence and the recurrence time of Eos-CRSwNP. A ROC curve revealed that a tissue LER value < 0.67 predicted long-term Eos-CRSwNP recurrence with 72.73% sensitivity and 82.35% specificity (area under the curve  =  0.789).

Conclusion: Tissue LER is strongly associated with Eos-CRSwNP recurrence and may play a key role in predicting long-term Eos-CRSwNP recurrence.

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来源期刊
CiteScore
5.60
自引率
11.50%
发文量
82
审稿时长
4-8 weeks
期刊介绍: The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
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